Assistant Professor, University of Washington, Genome Sciences. Previous: JSMF Fellow, Berkeley EECS ♡: Computational biology, evolutionary dynamics, quantitative immunology https://dewitt-lab.github.io/ [disclaimer: opinions mine] 🇺🇸🚫👑
I want to rotate in Phil's lab.
Phil AbituaAnnual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil
Spectacular preprint led by @sydsat.bsky.social in @ohnolog.bsky.social lab, @uwgenome.bsky.social. Neutrophils precede gastrulation in killifish and rapidly patrol the yolk. (1/2)
Early immune cell development precedes gastrulation in annual killifishDuring embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...doi.orgEnjoying those top 1% preeps, thanks @qedscience.bsky.social!
Christophe 🔬 LeterrierInteresting effect of z҉f҉k҉j҉h҉m҉l҉j҉ on g҉h҉f҉j҉g҉f҉k҉
"The spokesperson went on to describe the platform’s next phase, which seeks to score preprints in real time, reducing the interval between sharing one’s work and feeling terrible about it to under one minute."
In PreparationI've learned a lot from this community at various meetings since I was a PhD student. I'm looking forward to this one!
John Tsang6th iteration of the Physics & Computation in Immunology meeting will be at Yale CSEI @yalecsei.bsky.social Sep 28–30. With Arup Chakraborty, Michael Lässig, @thearmita.bsky.social & Alex Walczak. Speakers from Princeton, Cambridge, Harvard, MSK, UCSF & more. Free. 120 spots. Deadline Sep 6.
This started in 2019 as daydreamy PhD student musings with Tatsuya Araki. We're as excited as ever about germinal centers as a platform for experimental evolution. Many thanks to PIs @victora.bsky.social @matsen.bsky.social, co-1st authors Ashni Vora and Tatsuya, and many other key collaborators!
Replaying germinal center evolution on a quantified affinity landscapeAntibody affinity maturation results from a somatic evolutionary process that takes
place in the germinal center. A “parallel replay” experiment on germinal center B
cells reveals the evolutionary for...www.cell.comMarc Feldman and Jessica Riskin with another withering critique of a "sociogenomics" popularization: "...you can’t add or subtract factors that interact, such as genetic and environmental influences. How much of a rainbow’s formation is due to moisture in the air and how much to sunlight?"
Not in Your Genome | M.W. Feldman, Jessica RiskinGenerations of “sociobiologists” have tried and failed to argue that genetic analysis offers the key to understanding social inequality. A new book fares no better.www.nybooks.comGame over, phylogeneticists! New DNA foundation model "Carbon" reconstructs the tree of life. 🙃 huggingface.co/spaces/Huggi...
A nice finding on phylodynamic identifiability: Louca-Pennell congruence classes collapse to a unique model in settings where mutation is associated with birth events (e.g. cell division).
Information on hidden birth events restores identifiability in phylodynamic inferenceThe parameters of many classes of birth-death processes cannot be inferred uniquely from phylogenetic trees: infinitely many parameter combinations yield the same distribution of phylogenetic trees. H...arxiv.orgArc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis. Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6... Blog: dewitt-lab.github.io/posts/2026-0...
Additivity is all you need?Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis.dewitt-lab.github.io