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Профиль

Wehner lab | Neuroregeneration

Профиль Vively

Neuroregeneration Group @unicologne.bsky.social, @MPI-ScienceOfLight.bsky.social & https://mpzpm.mpg.de/. #fibroblast #ECM #SCI #regeneration #mechanics #zebrafish. Skeets by DW, views are my own.

Congratulations to everyone involved, especially the two joint first authors, Nora and Thomas! Thanks also to the four reviewers for their helpful comments, which improved the manuscript. #SCI, #Brillouin, #regeneration, #zebrafish, #AFM, #fibroblasts, #neutrophils

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cthrc1a+ fibroblasts release pro-inflammatory and immunosuppressive cytokines to induce and subsequently resolve the acute inflammatory phase, thereby establishing a lesion microenvironment with regeneration-permissive mechanical properties.

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We describe the identification of a transient population of cthrc1a+ fibroblasts with a less differentiated, non-fibrotic profile that possess dual functions in modulating inflammation.

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We show that, unlike mammals, the regulatory interplay between fibroblasts and immune cells is required for axon regeneration after spinal cord injury in zebrafish.

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Congratulations Sumeet! 🥳. Very well deserved. What a win for Shiv Nadar University. Looking forward to continuing our collaborations in the future.

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