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Out now in @science.org Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders | Science www.science.org/doi/10.1126/...

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disordersLysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...www.science.org

My choice this week in @science.org Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets www.nature.com/articles/s41...

Out now in @science.org A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin | Science www.science.org/doi/10.1126/...

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatinThe metabolite α-ketoglutarate (αKG) is required for chromatin demethylation, but mechanisms that control αKG abundance in the nucleus are poorly defined. We designed a biosensor to monitor this metab...www.science.org

My choice this week in @science.org Roman Polishchuk, Franck Perez and collaborators A coordinated transcriptional program controls de novo Golgi biogenesis link.springer.com/article/10.1...

Last chance to apply for Associate or Senior Editor in Neuroscience and Regenerative Medicine for Science magazine @science.org jobs.sciencecareers.org/job/679035/a...

Associate or Senior Editor - Washington D.C., Cambridge, UK job with American Association for the Advancement of Science | 679035Join the editorial team at Science! We are seeking a full time Associate or Senior Editorjobs.sciencecareers.org

Take a look at this new paper in @science.org Reversible suppression of autophagy in a mouse model reveals neuronal resilience | Science www.science.org/doi/10.1126/...

Reversible suppression of autophagy in a mouse model reveals neuronal resilienceImpairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains uncle...www.science.org

Check out this new work out now in @science.org Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation | Science www.science.org/doi/10.1126/...

Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammationStratified epithelial differentiation involves transcriptional and proteomic remodeling. Here, multiomic profiling implicated ubiquitin and related posttranslational networks in differentiation dynami...www.science.org

Out now in @science.org Antibiotics stimulate protein transfer to persister cells | Science www.science.org/doi/10.1126/...

Antibiotics stimulate protein transfer to persister cellsThe exchange of biological matter between bacterial cells drives adaptation and evolution. However, whether bacteria can exchange functional proteins remains unclear. In this work, we found that antib...www.science.org

@science.org is look for a new Biology Perspectives editor to join our commentary team. Join us in Cambridge UK or Washington DC! recruiting.ultipro.com/AME1123ASEM/...

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Just published in @science.org The oscillatory biology of sleep: Linkage to dementia | Science www.science.org/doi/10.1126/...

The oscillatory biology of sleep: Linkage to dementiaDuring wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity into a coordinated brain rhythm. During sleep, the ma...www.science.org

@science.org is looking for a new editor to look after regenerative medicine and neuroscience submissions. Come join us! Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...

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My choice last week in @science.org Deltaviruses spread through a viral Trojan Horse 10.1016/j.cell.2026.01.037

Print version out now in @science.org Microtubule dynamics control the direction of cardiomyocyte growth | Science www.science.org/doi/10.1126/...

Microtubule dynamics control the direction of cardiomyocyte growthThe adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...www.science.org

Couldn't have put it better myself!

Just out First Release in @science.org Microtubule dynamics control the direction of cardiomyocyte growth | Science www.science.org/doi/10.1126/...

Microtubule dynamics control the direction of cardiomyocyte growthThe adult heart grows by addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. Here, we found that microtu...www.science.org

My choice this week in @science.org RCC1 depletion drives protein transport defects and rupture in micronuclei doi.org/10.1083/jcb....

Out now in @science.org Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shapeBacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In m...www.science.org

Just published in @science.org Stem cell control in the lung by an autocrine injury-activated Igf complex | Science www.science.org/doi/10.1126/...

Stem cell control in the lung by an autocrine injury-activated Igf complexStem cells proliferate after injury to repair damaged tissue, and chronic injury can promote cancer. However, the injury-activated signals and regulatory mechanisms, and their relationship to cancer, ...www.science.org

Please join us online tomorrow! @science.org and Westlake online symposium - Translational control by ribosome heterogeneity

Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...