Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social . www.biorxiv.org/content/10.1101/2025.06.02.657420v1
Incredible work to understand CO adaption by an highly unusual mechanism in one of our favourite anaerobes. www.nature.com/articles/s41...
A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide - Nature CommunicationsCarbon monoxide (CO) present in syngas severely inhibits growth of many acetogens. Here, the authors adapt, characterize, and engineer utilization of CO as sole carbon and energy source by the thermop...www.nature.comThis 🧵 about the evolutionary implications by my good friend Georg the mastermind behind evolutionary analysis and understanding is a must read for everyone who wants to know how methanogenesis and N2 fixation are evolutionary connected. It's quite an evolutionary bomb.
georghochbergThis is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.
One of the largest open questions in anaerobic metabolism solved. The best work of my lab yet, performed by the incredible hard working, talented and motivated coworkers: @fidelormz.bsky.social , @sophia-pa.bsky.social and @rnfr2d2.bsky.social. I am a proud PI today! www.nature.com/articles/s41...
Structure of the ATP-driven methyl-coenzyme M reductase activation complex - NatureThe structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a uniqu...www.nature.comVery proud to share our latest work from the lab. Together with @kailalab.bsky.social and Müller Lab. We found such an elegant mechanism - Charge follows charge. The positive Na+ follows the negative electron across the membrane and back. rdcu.be/ecCmr
Molecular principles of redox-coupled sodium pumping of the ancient Rnf machineryNature Communications - The Rnf complex is a key respiratory enzyme of anaerobes and nitrogen-fixing bacteria. Here, the authors combine structural, computational, and biochemical experiments to...rdcu.be