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Профиль

Dr. Schiracha (Schirra)

Профиль Vively

Former Naval Nuclear Instruction Officer. Biophysics and Virology Postdoctoral Researcher. Experience in education, outreach, team building, and project management. Cliffe Lab, University of Virginia. Ideas are my own & do not represent my lab/organization

I keep hearing "This isn't #biologicallyrelevant because these are HeLa cells or CaCo cells", how about instead you start asking what does this say about #cancer cells and/or/vs non-immortalized cells. That data isn't garbage, this is so frustrating. #BigPicture, people! think bigger.

120

I would settle for a "Fabric of the Cosmos" style series with the (spoken as in The Ohio State University) Sean M. (Master of the universe) Carroll.

Sean Carroll

Gotta convince Christopher Nolan to make a film about the foundations of quantum mechanics.

100

If your lab needs a logo hmu! (No charge) Check out cliffelab.com for the new lab #logo and i even put an #Easteregg in the homepage. I will also generate a logo deck for different scenarios and a favicon to show up on internet tabs and favorite menus.

Cliffe Labcliffelab.com
262

1 month into my new #Postdoc position and so far its going great. I have already generated some data, I have 2 drafts of #SpecificAims for different potential projects I made the lab a new #website, and I have complete mental #burnout everyday in a good way and Im loving it.

031

Downloading 4tb of #data over wifi from Europe over the weekend and just wishing I had grabbed that ethernet cable from my old lab. 250gb down -_- atleast its the weekend. See you Monday, data! #cryoET ❄️🔬

010

And just like that the dreams of grad students obliterated... While the true visionaries step forward and look for the next step...at the keyboard and at the bench. Herpesviruses are related to phages. Maybe PherpAHerpe doesn.t sound so good... Meh, all is fair in war for science. #biosky

Rob Edwards

Starting with the DNA sequence of a #phage genome, #PholdAPhage will create a 3D reconstruction of the complete phage, almost like you did cryoEM on it! Check out Renee's awesome software github.com/reneegreen81... to assemble unknown phage particles one protein at a time

000

I vote for the normalization of the term "in vitreo" for cryoEM structures to sooth the brains of cell biologists that insist the cryoEM structure is not the native structure. (It is as close as we can get). This should both satisfy their thirst and aggravate them bc it looks like "in vitro"

Archer's Iconic 'Uh, Phrasing?' MomentALT: Archer's Iconic 'Uh, Phrasing?' Momentstatic.klipy.com
121

20 years of papers saying a protein is in some SUB-compartment in a cell. Reading... reading... some fluorescent microscopy... a couple gels... ABSOLUTELY NO high resolution nor high confidence metrics putting that protein INSIDE that compartment. I think its on the outside. #biosky #science

Reina Hardesty: Once I Make My Mind Up, That's ItALT: Reina Hardesty: Once I Make My Mind Up, That's Itstatic.klipy.com
010

Vegetative electron microscopy is what we did in the early 2000s when you had to manually pick targets and image on film for multiple days.

STCmicrobeblog

has anyone else ever run into that annoying glitch when trying to copy two-column text from a PDF? the twisted history of "vegetative electron microsccopy" is nicely dissected in the below 🧵 by @jamesbicycle.bsky.social

100

A promiscuous protein binder with many transient interactors in a single pathway can be as/more potent of a switch as a single high affinity binder at regulating a pathway. Biology is not an 'engineered system", its not "survival of the fittest", it is whatever works to an advantage w/i the domain

001

Still in the honeymoon phase of joining a new lab, but I honestly have not been this excited to present at lab meeting since second year of grad school. Digging through the literature and finding a huge hole that has been hidden because of a 10 year old analysis that was interpreted.... questionably

000

Science is not about your personal opinions or personal experiences for that matter. It's about defining a space in which to talk about the universe. If you fight the science, science will still help you, you just won't understand how and that is okay with us. We move forward for you in spite of you

000

Biophysics used to be the field of applying mathematical principles of physics to biology, but biology has largely fallen in line with this. Biophysics today is more about bridging fields and scrutinizing methods across disciplines. Bio(Ph)ysics it's what's for breakfast!

231

Just because you don't understand something doesn't mean you can't talk about it. What it does mean is that you should listen more and shut down others less. Injecting your one off anecdote into a scientific conversation as evidence is free speech but its not helpful

000
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