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Профиль

Ewan St. John Smith

Профиль Vively

👨🏻‍🔬& 👨🏻‍🏫🏳️‍🌈Neuroscientist in Cambridge UK interested in the neurobiology of pain and everything to do with naked mole-rats. 🏃🏻‍♂️, 📖 & 🤘

96% humidity was a bit of a killer & so took it easy on the Northern Rail Trail: 🏃🏻‍♂️ = ✅

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Flew into Boston late last night for the musculoskeletal GRS/GRC - hopefully, this short little run will get my musculoskeletal system (& brain!) going keep any jet lag at bay: 🏃🏻‍♂️ = ✅

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Bit cooler today & even saw some puddles after last night’s rain! Friday short 🏃🏻‍♂️ = ✅

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Still playing catch-up on sleep & rather warm out, but 🏃🏻‍♂️ = ✅

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Been a good #PainResearch day for our lab in @phar.cam.ac.uk with 2 papers out in Journal of Neuroscience: 1. Led by @mayadannawi.bsky.social focuses on the impact of Prdm12 overexpression in adult sensory neurons www.jneurosci.org/content/earl..., walkthrough 👉 bsky.app/profile/psal...

AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in female miceInflammatory joint pain features in numerous musculoskeletal disorders that affect millions globally. The Prdm12 gene encodes a conserved zinc finger transcriptional regulator expressed selectively in...www.jneurosci.orgEwan St. John Smith

New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch

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Excited to see our paper now out in J Neurosci @sfnjournals.bsky.social examining how MSC-EVs regulate sensory neuron activity. More info. 👇- congratulations all! www.jneurosci.org/content/earl...

Mesenchymal stem cell-extracellular vesicles deliver microRNAs that prevent nerve growth factor-induced sensory neuron sensitizationOsteoarthritis (OA) affects 600 million individuals globally, pain being a hallmark symptom. Emerging clinical evidence supports the use of mesenchymal stem cells (MSCs) and their extracellular vesicl...www.jneurosci.orgEwan St. John Smith

🚨New pre-print🚨 We found before that mesenchymal stem cell extracellular vesicles (MSC-EV) ⬇️ pain/neuronal sensitisation in 🐭 osteoarthritis (OA) See: x.com/psalmotoxin/... & acrjournals.onlinelibrary.wiley.com/doi/10.1002/... Now we've an idea how MSC-EVs work! www.biorxiv.org/content/10.6...

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Now out in J Neurosci @sfnjournals.bsky.social - read more 👇 about the impact of overexpressing Prdm12 in adult 🐁 - congratulations all! www.jneurosci.org/content/earl...

AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in female miceInflammatory joint pain features in numerous musculoskeletal disorders that affect millions globally. The Prdm12 gene encodes a conserved zinc finger transcriptional regulator expressed selectively in...www.jneurosci.orgEwan St. John Smith

New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch

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Another epic week in 🇨🇳 has finished: interesting meeting & knowledge exchange of all things animal research welfare related coupled with wonderful hospitality & sightseeing extravaganza…hopefully, this short 🏃🏻‍♂️ = ✅ on limited sleep will keep the jet lag at bay!

Ewan St. John Smith

Great to be back in China for the CALAS International Symposium on the Welfare & Ethics of Laboratory Animals, myself & Cathy Wilson representing @phar.cam.ac.uk, talking about naked mole-rats & cardiac regeneration, respectively.

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Warm & sunny start to the day in Hohhot: 🏃🏻‍♂️ = ✅

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Great to be back in China for the CALAS International Symposium on the Welfare & Ethics of Laboratory Animals, myself & Cathy Wilson representing @phar.cam.ac.uk, talking about naked mole-rats & cardiac regeneration, respectively.

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Arrived in Hohhot, Inner Mongolia, late last night for 11th International Symposium on the Welfare and Ethics of Laboratory Animals - always great to be back in China, morning sleep-deprived river run should hopefully see of the jet lag: 🏃🏻‍♂️ = ✅

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Sunday 🏃🏻‍♂️ = ✅

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Happy #Caturday 😺😺😺

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Greyer & cooler start to the day today: Friday short 🏃🏻‍♂️ = ✅

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Such a cool piece of work, great seeing it finally out, well done Mohammed, Gary and team! Great to learn ever more about naked mole-rats!

Mohammed Khallaf

Our new paper is out in @nature.com! We uncovered how a naked mole-rat queen 👑 controls an entire colony: a natural contraceptive scent that suppresses reproduction in other females! A remarkable mammalian parallel to bees and ants! 🐝🐜 @garyrlewin.bsky.social youtu.be/enfv3zJrWKM?...

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Grey & breezy start to the day: 🏃🏻‍♂️ = ✅

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Video up now on the @painresforum.bsky.social You Tube channel in case you weren't able to attend live: www.youtube.com/watch?v=lalu...

PRF Webinar: Osteoarthritis Pain Research on July 10, 2026YouTube video by Pain Research Forumwww.youtube.comEwan St. John Smith

Excited to be moderating this @painresforum.bsky.social webinar on all things osteoarthritis & pain on July 10th, registration 👉 painresearchforum.org/register-for... #PainResearch #neuroskyence #immunosky

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Pleasant breeze, but still rather warm: 🏃🏻‍♂️ = ✅

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Happy #Caturday 😺😺😺

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Still too warm & insufficient sleep: Friday short 🏃🏻‍♂️ = ✅

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