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Профиль

Paul Bleicher

Профиль Vively

MD/PhD, Academia => Biotech => Pharma/HealthIT => PE/VC. Immunology, medicine,dermatology, clinical trials, EDC, RWE, AI

The headline and subhead are laughable and wrong. Nose swabs aren’t part of a routine physical. And then the article (sadly behind a paywall) seems to start with throat swabs - which are ALSO not part of a routine physical. Tongue depressors are, but who cares at this point. Journalism is dead.

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The most amazing pizza experience of my life. Stunning. Don’t miss it. Get the tasting menu. www.thecommonwanderer.com/blog/pepe-in...

Eating The Best Pizza in the World at Pepe in Grani, Caiazzo, Italy | The Common WandererA pizza pilgrimage to try the ‘best pizza in the world’ at Pepe in Grani, Caiazzo, Italy, becomes a story of expectations. Is such a thing as ‘the best pizza in the world’, and whether Pepe in Grani i...www.thecommonwanderer.com
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If today is December 19, 2019, then yes, you are correct. www.npr.org/2019/12/19/7...

Wakanda Was A U.S. Trade PartnerThe U.S. Department of Agriculture removed Wakanda from its list of free trade partners. A spokesperson told NBC it was a testing file and published by mistake.www.npr.org
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Excellent point and not accurately represented in both NY Times articles. They were nominated to be included in the bulk list, but were withdrawn. www.fda.gov/drugs/human-...

Substances in Compounding that May Present Significant Safety RisksCategory 2 of the Bulk Substances Nominated Under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Actwww.fda.gov
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Use the personalization features to tell it not to flatter you, etc. DM me and I can send you mine. It changes dramatically.

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Compounding pharmacies are regulated. They’re licensed and inspected by state boards of pharmacy, with FDA oversight that varies by the type (503A vs. 503B). And for office-use compounding, the active ingredients must come from the FDA’s approved bulk substances lists or be an approved drug.

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Improved infographic.

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Okay. Better one addressing your concerns.

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The icon could be clearer with 1 amino acid as a single dot. But placing peptides “between” amino acids and proteins implies a biosynthetic sequence. Peptides may be synthesized directly, cleaved from larger proteins, or manufactured chemically. The diagram is compositional, not a pathway.

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Others with some benefit include prostate and pancreatic (also in high risk individuals).

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As stated, needs to be studied for each cancer. Today we know clearly that colorectal cancer is the standout example of the benefits of screening. Also cervical, breast, and lung (in high risk individuals) mortality all have been shown to benefit from screening. And a smattering of others.

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Hey Scott, why didn’t you simply repost or quote my original with your lead sentence, instead of using it almost verbatim? It just seems the right thing to do, no? bsky.app/profile/pble...

Paul Bleicher

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

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For those less familiar with the basics, an explanatory infographic on amino acids, proteins, and peptides and the 7 compounds before the committee yesterday and today.

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Regarding whether this will at least improve safety and controls in manufacturing (as in the chatGPT comment, above), this from the March NY times article above:

Paul Bleicher

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

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These 7 peptides - 4 from yesterday’s hearing and 3 from today’s were removed from the list in 2023 as noted in this NY Times article. www.nytimes.com/2026/03/31/h...

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For the curious, the makeup of the panel in 2024.

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And 3 other peptides. There are 3 more up for discussion today. The committee deliberations are ongoing until 4-5 today and can be viewed live at www.youtube.com/live/xXM5ecH...

July 24, 2026 Meeting of the Pharmacy Compounding Advisory Committee (PCAC)YouTube video by U.S. Food and Drug Administrationwww.youtube.com
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No. See my comments.

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A more precise description is: The FDA advisory panel voted to recommend adding BPC-157 to the FDA’s 503A Bulks List, which would allow compounding pharmacies to prepare the peptide from bulk active ingredient for individually prescribed patients, provided the FDA accepts the recommendation.

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As such, the original post should have said “recommended approval” instead of approved.

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