Профиль

New in NEJM Voices: A patient in shock forced @iwashyna.bsky.social to consider how to respond to the limits of his own knowledge and those of the medical field at large. Read his latest: https://nej.md/4yVP1fO

A 60-year-old man presented with a 1-month history of postprandial epigastric pain. The physical examination was normal, with no jaundice or abdominal tenderness observed. Read the full case details and submit your answer or see how others responded: https://nej.md/IC07302026

Want to gain a deeper understanding of the analyses and considerations that guide decisions about which articles to publish in NEJM? And insight and knowledge that will impact your career going forward? If so, consider applying for the 2027–28 NEJM editorial fellowship. 👉 https://nej.md/3cCQajB

TALAPRO-3: Talazoparib–enzalutamide has been shown to improve survival in patients with metastatic prostate cancer, particularly those with alterations in homologous recombination repair genes. Research findings in this population are summarized in a new Quick Take video. https://nej.md/4fuadBY

Love watching @glaucomflecken.bsky.social explain research published in NEJM? If so, then good news! He and his fellow anchors have a new weekly news podcast called Medlines, designed to help everyone in health care stay in the know. Listen wherever you get your podcasts: medlinespod.com/follow.

Many disorders that cause optic disk edema can produce retinal fluid and even macular exudates in a stellate pattern. The development of pronounced radial macular exudates, known as a macular star, suggests neuroretinitis. Learn more: https://nej.md/4wsAYMQ

A 45-year-old man presented with a 2-month history of worsening pain and swelling in his right shoulder. A radiograph showed destruction of the humeral head with a free-floating humeral diaphysis. Read the full case details: https://nej.md/4wzHz8s

New in NEJM: PARP Inhibition and ADT in Prostate Cancer (TALAPRO-3) Teclistamab in Previously Treated Multiple Myeloma (MajesTEC-9) Naᵥ1.8 Inhibitor for Acute Pain Iptacopan in IgA Nephropathy (APPLAUSE-IgAN) Explore the issue: https://nej.md/current-issue

In a new NEJM Voices blog post, @paulsaxmd.bsky.social shares what cyclosporiasis outbreaks, past and present, can teach us. Learn more and sign up for email alerts: https://nej.md/4x7zAiL

A new review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies. Read the full review: https://nej.md/4fskK0r

The selective Naᵥ1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty. Full trial results: https://nej.md/4fHl0HJ

Among 14 pregnancies in 13 patients with autoimmune disease who had undergone CAR T-cell therapy, early maternal and neonatal outcomes appeared reassuring, with no disease relapses reported and 8 healthy infants born to date. Read the full report: https://nej.md/4fM65Mv

Ebola virus continues to be a global threat. In a phase 1 study, an inactivated Ebola virus vaccine was tested in healthy volunteers for safety and immunogenicity. Read the full study results: https://nej.md/4wtlmIZ

Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. Full phase 3 ISLEND-1 trial results: https://nej.md/4b4s7sh #AIDS2026

Today’s real-world case on Doctordle is from NEJM! A 5-year-old boy presents to the ED with fever and rash. See how many tries it takes you to determine the diagnosis at doctordle.org.

In the phase 3 SCOUT-HCM trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo. Full trial results and Research Summary: https://nej.md/3Q06X6I

In a new NEJM Voices blog post, @mkittlesonmd.bsky.social writes that practicing medicine not only provides clinicians with intellectual fulfillment — but allows them to bear witness to inspiring life stories. Learn more and sign up for email alerts: https://nej.md/3RxK77W

Current HIV treatment guidelines worldwide recommend that persons with HIV infection start antiretroviral therapy (ART) regardless of symptoms, signs, clinical stage of disease, CD4 cell count, or HIV RNA level. Learn more about ART in a new review: https://nej.md/4wn6mg2

Observational evidence suggests that the four-component meningococcal B vaccine (4CMenB) may reduce gonorrhea risk. In this randomized trial, 4CMenB did not result in a lower incidence of 𝘕. 𝘨𝘰𝘯𝘰𝘳𝘳𝘩𝘰𝘦𝘢𝘦 infection than placebo. Full GoGoVax trial results and Research Summary: https://nej.md/4wv9Qwi

Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended. Learn more: https://nej.md/4bK7CBj

Видео