Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions
📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...
Congratulations to the authors on their #NARCANCER publication! 🎉 Deleterious #SMC5/6 variants may predict higher #tumormutationalburden and better responses to #immunotherapy, highlighting their potential as #biomarkers for #precisioncancertherapy.
Bill Dynan - NAR Cancer EditorCan SMC5/6 status help guide precision cancer therapy? A new NAR Cancer study links deleterious SMC5/6 variants to tumor mutational burden and immunotherapy responses, driven via POLE dysfunction and mismatch repair deficiency.https://academic.oup.com/narcancer/article/8/2/zcag012/8688771
New research in #NARMolecularMedicine shows that #musclestemcells retain intrinsic #inflammatory changes, with aberrant #TNFα signaling and reduced #H3.3 impairing muscle regeneration, pointing to #newtherapeutic opportunities in #dermatomyositis beyond #interferon. 🧬 doi.org/10.1093/narm...
📣 Applications are open for the next NAR Early Career Investigator (ECI) Advisory Board cohort! Work with Executive Editors, help shape journal strategy, and gain insight into peer review during a 2-year term. Apply by 1 Nov 2026: lnkd.in/g233ZCAf #ECR #NAR #AcademicPublishing #MolecularBiology
⭐ #NARBreakthrough ⭐ 🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/... @igmm-montpel.bsky.social
⭐ #NARBreakthrough ⭐ 🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐ 🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social
Big congratulations to the authors! 🎉🦠 Using RNA-seq, this study uncovers overlooked viral RNA species and supports a premature termination model for astrovirus subgenomic RNA synthesis, resolving a long-standing replication mystery. 🔬✨ #NARMolecularMedicine #Virology @universitypress.cambridge.org
Valeria Lulla🚨 New paper from the lab! 🚀 We explore “The dynamics and strategy of RNA replication in astroviruses”, now out in NAR Molecular Medicine. Many thanks to all co-authors and congratulations to David Noyvert on his first first-author paper🎉 doi.org/10.1093/narm...
📣 Applications are open for the next Editor‑in‑Chief of NAR Cancer! 📣 Lead an open‑access journal at the forefront of nucleic acids and cancer research. We welcome applications until 1st Aug 2026. More details: academic.oup.com/narcancer/pa... #NARCancer #EditorInChief #CancerResearch
⭐ #NARBreakthrough! ⭐ New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding. 📖 Read here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...
How do memories last a lifetime when proteins turn over in months? A new NAR review by Peter Cook suggests long‑term memory may stem from transcriptional gene clusters and even pyrophosphate shaping calcium signals. 📖 doi.org/10.1093/nar/... #LongTermMemory #Transcription #ReviewArticle
🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA
⭐ #NARBreakthrough ⭐ New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource
⭐ #NARBreakthrough! ⭐ 🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers. 📖 Read here: doi.org/10.1093/nar/...
🔬 Modern #bioinformatics workflows are complex and hard to reproduce. #systemPipeR helps researchers design, run, and track analysis #pipelines in one framework, integrating R + bioinformatics tools, HPC support, and automated #reports for #transparency. Read more doi.org/10.1093/narg... #NARGAB
✨A new review in #NARMolecularMedicine explores how #mitochondrialDNA inheritance, copy number changes, and coordination with the nuclear genome shape development, and how #AssistedReproductiveTechnologies may disrupt this balance. Read the review here: doi.org/10.1093/narm... #EditorsChoice
⭐ #NARBreakthrough ⭐ 🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...
Huge congratulations to Tomáš Brůna @tomasbruna.bsky.social and John T. Lovell @jotlovell.bsky.social on their new paper in NAR Genomics and Bioinformatics!! 🎉🚀 Absolutely fantastic work—excited to see this contribution making waves in the field! 👏🔥
John LovellThis article is now published! academic.oup.com/nargab/artic... We’ve added a few new analyses. First off, we show that, while gene presence absence variation (PAV) scales with evolutionary distance in both plants and animals, the base level and rate of accrual are both twice as high in plants.