#1 molecular motor, cytoskeletal motors, cytoskeletal filaments, filament dynamics, cell migration, mechanobiology, morphogenesis
www.biorxiv.org/content/10.6...
Calmodulin requires Ca2+ to integrate into the spindle pole body and modulate the cytokinetic ring constriction in fission yeast cellsAlthough calmodulin is best known as a calcium sensor, it also possesses Ca2+-independent functions, exemplified by the surprising finding that the budding yeast cells remain viable using a calmodulin...www.biorxiv.orgwww.biorxiv.org/content/10.1... Naegleria amoebae seek confinement and crawl persistently through narrow spaces
www.biorxiv.org/content/10.6... Motor Occupancy Defines Emergent Mechanical States in Cardiac Myosin Ensembles
www.biorxiv.org/content/10.6... Myosin 5A mediates membrane-associated periodic skeleton reassembly during axon regeneration in response to ROCK-2 inhibition
www.molbiolcell.org/doi/10.1091/... A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1
awesome postoc/training opportunities in the Hunter lab!!
Ginger HunterWe are hiring in two positions! Links to the job description on our lab website here: sites.google.com/view/hunterl... 1. A postdoc (preferably w/ fly experience) to work on Notch signaling in cell morphogenesis. If you know of a recent grad in the DMV, or someone looking to move here, pls share!
www.molbiolcell.org/doi/10.1091/... Differential effects of tropomyosin paralogs on mitochondrial dynamics in Saccharomyces cerevisiae
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets: Cell Reports www.cell.com/cell-reports...
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootletsVijayakumaran et al. present a three-dimensional nanoscale reconstruction of human
airway multiciliogenesis, revealing extensive organelle and architectural remodeling.
They show that rootlets form ev...www.cell.comwww.nature.com/articles/s41...
Resolving endogenous protein organization in cells with nanometer resolution - Nature CommunicationsEilts and colleagues combine a double-homogenisation expansion microscopy approach with dSTORM, revealing molecular details of endogenous protein complexes, including microtubules, clathrin lattices a...www.nature.comMicrotubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future - Walczak - Cytoskeleton onlinelibrary.wiley.com/doi/10.1002/...
Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the FutureThe microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule-associated proteins...onlinelibrary.wiley.comwww.biorxiv.org/content/10.6... Systematic functional genetic analysis of cell-substrate adhesion
www.biorxiv.org/content/10.6... Layered helical order reveals assembly states in podosome actin networks
www.biorxiv.org/content/10.6...
Deletion of cytoplasmic β/γ-actin in the mouse heart protects from disease by augmenting sarcolemma stabilityThe actin cytoskeleton of the cardiomyocyte is organized into two structurally and functionally distinct filament networks. The sarcomeric thin filaments, built primarily from cardiac α-actin (αCA), g...www.biorxiv.orgwww.biorxiv.org/content/10.6...
Matrix Stiffness-driven FAK Splicing Tunes Cell MechanosensingThe extracellular matrix (ECM) stiffness influences many physiological and pathological processes. Cells can sense mechanical changes within the ECM through mechanosensors, most notably through the fo...www.biorxiv.orgwww.biorxiv.org/content/10.6...
Serotonin Receptor Signaling Promotes Amoeboid Migration of Melanoma Cells Through cAMP/PKA ActivationMelanoma cells frequently utilize bleb-driven amoeboid migration to navigate confined microenvironments during metastasis. Through a morphology-based drug repurposing screen, we identified the anti-mi...www.biorxiv.orgMechanical forces stimulate Golgi export rupress.org/jcb/article/...
www.molbiolcell.org/doi/10.1091/... Kinesin-3 KIF1A functions as a diligent worker and its functionality is regulated by the ubiquitin-proteasome system.
www.sciencedirect.com/science/arti... The actin crosslinker Fimbrin is required for force sensing at tricellular junctions
Legendary myosin researcher Jim Sellers retires after many years of making significant contributions to the field and being an unfailingly generous to colleagues - alway sharing materials, insights and wisdom. A symposium honoring Jim will be held in Sept. www.nhlbi.nih.gov/events/2026/...
Scientific Symposium Honoring Dr. James R. SellersRetirement symposium honoring Dr. James R. Sellers’ contributions to myosin studies. Leading scientists in the field will be present.www.nhlbi.nih.gov