I think all models have a place and we can learn from all of them. People have different ways and ideas of how to mimic something we cannot study in humans. The failure is often at the level of acknowledging the limitations all models have and build into the puzzle of how things happen in a human.
Very interesting and important work. When we found that antibiotics can accumulate in organelles we speculated that this could be the case for other drugs in other diseases - and you show this here! Congratulations everyone
Beyond the exciting findings, an interesting fact to me in this project was how different are mycobacteria at the time of transformation and how better protocols are needed as there is no one-fits-all. Congratulations everyone!
This was a great collaboration with our longstanding collaborators @luizcarvalholab.bsky.social and Rachel Lai (not on Bluesky?!)- Luiz has a compelling collection of mycobacteria (!!) and we only picked 12 this time...😅
She found that many NTMs are restricted by low pH in macrophages. The data suggest that specific environmental adaptations may determine the opportunistic potential of NTMs. Parise's work also discovered some beautiful cell biology of NTMs in human macrophages that we are exploring. Stay tuned!
Very relatable. Number of items and system is similar. Only difference is that I do account for the time every item needs (e.g. from 1h to one day and level of distraction allowed), I add deadlines to them too. sigh 😂
