Профиль

Thanks, Mia! Would love to hear your feedback :)

Beyond providing insight into the centromere paradox, this work demonstrates that complete chromosome reconstruction is now possible from wild-caught flies, opening new opportunities for population, functional, and quantitative genomics in Drosophila. Preprint here: www.biorxiv.org/content/10.6...

A conserved architectural domain shapes centromere evolution in DrosophilaCentromeres ensure faithful chromosome segregation despite being embedded within rapidly evolving repetitive DNA, a contradiction known as the centromere paradox. While centromere identity is defined ...www.biorxiv.org

By generating the first Drosophila melanogaster chromosome assembly reconstructed through its centromere from a single fly, Alex found that centromere architecture remains conserved even as the underlying DNA sequence evolves rapidly. 3/4

In a new preprint, Ph.D. student @alesamano.bsky.social in my lab found that the answer may lie not in the DNA sequence itself, but in the conserved three-dimensional architecture of centromeric regions. 2/4

Thanks, Jeff!