🇨🇦🇭🇰 @EPFL_en protein production + structure facility 🇨🇭| ex @ubc @uwaterloo @unige_en | here for #proteins #structuralbiology #xray #cryoem #plants #mountains #politics #transit #urbanism 🐱🐈 staying for the #hottakes | My views here🧪🧬🌱🔬🏳️🌈
Tried a workflow to increase productivity. Theres a lot of in silico cloning to do that is between both GUI and text. Give it whatever base vector, define where you want it. Give it the sequences (or have it find them for you) and then output back the final sequences and a table ready for a CRO
Kelvin Lau @klausenhauser on 🙅♂️🐘🪡I feel like this is just some babble a untrained bachelor student will spit out. It also gives way too many options. It does show the power of how it can fetch all the data I do use daily, but its just not doing it in the way. I had to even tell it to compare its own designs with the PDB
finally tried it out with Coot 1.3.1 works great! just have to get used to the commands. but I wish there was a mutate binding.
Oli ClarkeAdded custom menus, including one to quickly add common monomers (detergents, buffers etc):
First being a scientist is bad now you’re just banned because you’re a foreigner.. and I paid for the product!
Kelvin Lau @klausenhauser on 🙅♂️🐘🪡Trying to help someone setup MCP for ChimeraX, wanted to see if Fable can do it. I cant even read a website on it anymore. Opus works fine.
Posted this in LinkedIn. Shameless advert for some new structures 👉 lnkd.in/gT9Be3tH. But more structural biologists here! Nice to have Claude control my ChimeraX. At least for visualizations and analysis I can see it really speeding up things. IF you know what you’re doing and what to ask for.
Might enjoy using this tool and see if it’s the model building or innate to the dataset! CrystalBoltz soniaminseokim.github.io/crystalboltz...
CrystalBoltz: End-to-End Protein Structure Determination via Experiment-Guided Diffusion<br>for X-Ray CrystallographyDeformable Neural Radiance Fields creates free-viewpoint portraits (nerfies) from casually captured videos.soniaminseokim.github.ioKelvin Lau @klausenhauser on 🙅♂️🐘🪡Calling all xray structure folks that have worked with denovo proteins. Do you suffer from high rfactors? Myself, someone else I know and now multiple structures all seem to suffer from this. Assuming we all tried our best in model building, what could be some causes?