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Профиль

John Lees

Профиль Vively

Pathogen informatics and modelling http://bacpop.org (Research group leader at EMBL-EBI - http://ebi.ac.uk/research/lees/)

⟳ Репост от John Lees

Very proud of this preprint out of my lab, our first (of hopefully many) host-microbe spatial transcriptomics paper. www.biorxiv.org/content/10.6... Amazing insights into P. aeruginosa biology and chronic airway disease @cysticfibrosis.org.uk @sangerinstitute.bsky.social @asthmaandlung.org.uk

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⟳ Репост от John Lees

Are you a computational immunologist or bioinformatician interested in impactful vaccine research? We're hiring a postdoc to join @psioxford.bsky.social work in vaccine immunology and evaluation, working on the ChAdOx1 Nipah vaccine. Please get in touch! my.corehr.com/pls/uoxrecru...

Job Detailsmy.corehr.com
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⟳ Репост от John Lees

As many people guessed... MenB vaccine catch up campaign incoming for students in England, Wales and Scotland www.bbc.co.uk/news/article...

Meningitis B vaccine to be offered to thousands of young people in JulyThe decision for the one-off vaccine programme follows the unprecedented outbreak in Kent this year.www.bbc.co.uk
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⟳ Репост от John Lees

The video recordings of the legend 2025 conference held last December on machine learning for evolutionary genomics are now online ! Feel free to have a look if you missed the conference. www.canal-u.tv/chaines/lisn...

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⟳ Репост от John Lees

Our new preprint is out! We train a transformer on gene order and gene content of bacterial pathogens, applying it to a range of epidemiological and evolutionary analyses (1/8) www.biorxiv.org/content/10.6...

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⟳ Репост от John Lees

Applications now open for the UNIL Summer School on Modelling for Evolutionary Biology (31 Aug–5 Sep 2026, Lausanne)! For PhD & postdocs interested in formal approaches to evolutionary ecology (incl. social evo, life-history, species interactions). Scholarships available, Pls RP! shorturl.at/fo1GA

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⟳ Репост от John Lees

How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...

www.science.org
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⟳ Репост от John Lees

Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes. www.biorxiv.org/content/10.6...

www.biorxiv.org
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⟳ Репост от John Lees

A quick rant on people vibe-translating our Rust libraries to other languages That's the second time in a week that I see new bioinformatics tools with a vibe-coded translation of our Rust libraries to C/C++. I have two major issues with that:

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⟳ Репост от John Lees

...because I'm also releasing ggCallaroo! This is an-easy-to-use snakemake pipeline that runs ggCaller, Panaroo and then functionally-annotates representative proteins using Bakta, all in one tool. github.com/samhorsfield...

GitHub - samhorsfield96/ggCallaroo: A snakelike pipeline combining ggCaller and Panaroo.A snakelike pipeline combining ggCaller and Panaroo. - samhorsfield96/ggCallaroogithub.com
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⟳ Репост от John Lees

Welcome, @stephlo.bsky.social, our new Team Leader for Protein Function. Find out how Stephanie’s experience in genomics shaped her approach to protein curation and AI integration. #ProteinScience #AI www.embl.org/news/people-...

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⟳ Репост от John Lees

New preprint where @lbobay.bsky.social and I were motivated by the fact that non-synonymous substitutions are commonly analyzed in molecular evolution studies, but the similarity of the amino acids being substituted is an understudied area. doi.org/10.64898/202...

doi.org
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⟳ Репост от John Lees

New paper showing that bacteria with more genes for cooperation can live in a broader range of habitats and that genes for cooperation are more more likely to be in the accessory genome www.pnas.org/doi/10.1073/... @lauriebelch.bsky.social

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⟳ Репост от John Lees

Delighted to see over 17 million new protein structure predictions from novel proteins in AllTheBacteria are now integrated into the AlphaFold Database at @ebi.embl.org ! Huge work from @gbouras13.bsky.social @oschwengers.bsky.social and friends to generate these. www.ebi.ac.uk/about/news/u...

AlphaFold Database welcomes community datasetsLatest AlphaFold Database update adds high-value datasets for microbial and viral proteins, generated by specialist communitieswww.ebi.ac.uk
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⟳ Репост от John Lees

Super excited to announce the release of gene and intergenic region annotation from the largest bacterial genome and MAG datasets available, including AllTheBacteria, GTDB, SPIRE, HRGM, mOTUs and MGnify - dereplicated and available from HuggingFace huggingface.co/AllTheBacteria

Hugging Face – The AI community building the future.We’re on a journey to advance and democratize artificial intelligence through open source and open science.huggingface.co
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⟳ Репост от John Lees

Meet Leonie Johanna Lorenz 🇩🇪, a Predoctoral Fellow at EMBL-EBI who is bringing mathematical modelling to microbes. Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵 www.ebi.ac.uk/about/news/p...

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