Very proud of this preprint out of my lab, our first (of hopefully many) host-microbe spatial transcriptomics paper. www.biorxiv.org/content/10.6... Amazing insights into P. aeruginosa biology and chronic airway disease @cysticfibrosis.org.uk @sangerinstitute.bsky.social @asthmaandlung.org.uk
Профиль
John Lees
Профиль VivelyPathogen informatics and modelling http://bacpop.org (Research group leader at EMBL-EBI - http://ebi.ac.uk/research/lees/)
Are you a computational immunologist or bioinformatician interested in impactful vaccine research? We're hiring a postdoc to join @psioxford.bsky.social work in vaccine immunology and evaluation, working on the ChAdOx1 Nipah vaccine. Please get in touch! my.corehr.com/pls/uoxrecru...
Job Detailsmy.corehr.comAs many people guessed... MenB vaccine catch up campaign incoming for students in England, Wales and Scotland www.bbc.co.uk/news/article...
The video recordings of the legend 2025 conference held last December on machine learning for evolutionary genomics are now online ! Feel free to have a look if you missed the conference. www.canal-u.tv/chaines/lisn...
Our new preprint is out! We train a transformer on gene order and gene content of bacterial pathogens, applying it to a range of epidemiological and evolutionary analyses (1/8) www.biorxiv.org/content/10.6...
Applications now open for the UNIL Summer School on Modelling for Evolutionary Biology (31 Aug–5 Sep 2026, Lausanne)! For PhD & postdocs interested in formal approaches to evolutionary ecology (incl. social evo, life-history, species interactions). Scholarships available, Pls RP! shorturl.at/fo1GA
How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
www.science.orgAlex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes. www.biorxiv.org/content/10.6...
www.biorxiv.orgA quick rant on people vibe-translating our Rust libraries to other languages That's the second time in a week that I see new bioinformatics tools with a vibe-coded translation of our Rust libraries to C/C++. I have two major issues with that:
...because I'm also releasing ggCallaroo! This is an-easy-to-use snakemake pipeline that runs ggCaller, Panaroo and then functionally-annotates representative proteins using Bakta, all in one tool. github.com/samhorsfield...
GitHub - samhorsfield96/ggCallaroo: A snakelike pipeline combining ggCaller and Panaroo.A snakelike pipeline combining ggCaller and Panaroo. - samhorsfield96/ggCallaroogithub.comWelcome, @stephlo.bsky.social, our new Team Leader for Protein Function. Find out how Stephanie’s experience in genomics shaped her approach to protein curation and AI integration. #ProteinScience #AI www.embl.org/news/people-...
New preprint where @lbobay.bsky.social and I were motivated by the fact that non-synonymous substitutions are commonly analyzed in molecular evolution studies, but the similarity of the amino acids being substituted is an understudied area. doi.org/10.64898/202...
doi.orgNew paper showing that bacteria with more genes for cooperation can live in a broader range of habitats and that genes for cooperation are more more likely to be in the accessory genome www.pnas.org/doi/10.1073/... @lauriebelch.bsky.social
Delighted to see over 17 million new protein structure predictions from novel proteins in AllTheBacteria are now integrated into the AlphaFold Database at @ebi.embl.org ! Huge work from @gbouras13.bsky.social @oschwengers.bsky.social and friends to generate these. www.ebi.ac.uk/about/news/u...
Super excited to announce the release of gene and intergenic region annotation from the largest bacterial genome and MAG datasets available, including AllTheBacteria, GTDB, SPIRE, HRGM, mOTUs and MGnify - dereplicated and available from HuggingFace huggingface.co/AllTheBacteria
Meet Leonie Johanna Lorenz 🇩🇪, a Predoctoral Fellow at EMBL-EBI who is bringing mathematical modelling to microbes. Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵 www.ebi.ac.uk/about/news/p...