Prof of Cognitive Neuroscience & Vice Dean at UCL, Fellow of the Royal Inst. of Navigation. I study how we remember, navigate & imagine space Photo: Our upcoming field research in the Marshall Islands https://spierslab.wixsite.com/wavesandwayfinding
Great cross-species large-scale analysis of data from @ayeletlandau.bsky.social and others on brain rhythms!
Earl K. MillerAre brain rhythms a steady hum or a brief buzz? Both. Alpha and beta activity are relatively sustained, helping maintain ongoing brain state, supporting its role in top-down control. Universal rhythmic architecture uncovers two modes of neural dynamics www.nature.com/articles/s41... #neuroscience
"..CA3 operates as a nonlinearly gated scene constructor and CA1 as a continuous landmark integrator to build and maintain the cognitive map." How visual scenes recruit spatial maps: threshold-gated activation in CA3 versus continuous integration in CA1 Inah Lee Lab: www.biorxiv.org/content/10.6...
How visual scenes recruit spatial maps: threshold-gated activation in CA3 versus continuous integration in CA1The hippocampal cognitive map is constructed from environmental sensory inputs, but the conditions that recruit a spatial map from a quiescent baseline remain unclear. Using a parametric virtual reali...www.biorxiv.orgReplay of procedural memory is independent of the hippocampus www.nature.com/articles/s41...
Replay of procedural memory is independent of the hippocampus - Nature NeuroscienceThompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error out...www.nature.com🚨 new lab preprint! Research from @gordonfeld.bsky.social during his DFG personal fellowship to my lab many moons ago: Global structure of new relational knowledge networks is represented in retrosplenial complex, and node-distance in hippocampus www.biorxiv.org/content/10.6...
Brenda Milner is a hero and 108!! She did a lot more than discover the hippocampus is linked to declarative memory, but that work is the most famous.
Admirable WomenNeuroscientist Dr. Brenda Milner is recognized as one of the fundamental founders of modern cognitive neuropsychology. She proved the hippocampus is essential for forming long-term "declarative" memory (facts, names & events). She was born #OTD in 1918--she's 108 years old today! #WomenInSTEM
The emergence of a novel CA1 spatial map requires direct entorhinal input From Kentros Lab. A useful result to help explain how cognitive maps get built www.biorxiv.org/content/10.6...
www.biorxiv.orgAre people super skilled at recognising faces also super skilled at navigation? Nope! No Association Between Face Recognition and Spatial Navigation: Evidence from Developmental Prosopagnosia and Super-Recognizers www.mdpi.com/2076-3425/15...
Very cool Hannah. Thant was my understanding that 'place cells' can switch, but the new data in MEC suggests the very spatial inputs stay spatial, but other less strong spatial cells can switch. Nice piece of the puzzle.
(((Dr Hannah Wirtshafter))) 🔬interesting!! I found a temporal task could "override" the place code in the hpc :) love this line of work www.biorxiv.org/content/10.6...
Is space & time coding in entorhinal cortex interchangeable? Cells switching between space & time as needed by task? For some cells yes, and other no: Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex www.biorxiv.org/content/10.6...
www.biorxiv.org"Here, we report a randomized, double-blind, phase 1b first-in-human trial in early AD, with safety and tolerability as the primary endpoint." Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer’s disease: a phase 1b, randomized, double-blind trial www.nature.com/articles/s41...
Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer’s disease: a phase 1b, randomized, double-blind trial - Nature MedicineA phase 1b trial shows that IBC-Ab002, a short-lived antibody that intermittently activates the peripheral immune system, is safe and well tolerated with trends in biomarkers in people with early Alzh...www.nature.com