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Профиль

grumpyoldscientist

Профиль Vively

Recovering federal regulator, molecular biologist, serious dog person

Lest all the other good news of the world distract you, here is a reminder we are sitting on a ticking time bomb. While having a war that is …about… oil.

Zack Labe

A data-driven picture of our rapidly changing planet - updated through June 2026... Download the graphic at zacklabe.com/climate-chan...

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Granted this is a relatively minor blip on the destruction of US education , but since New College was Rufo’s first hit job, I thought you should see what is in store for everyone else. State of FL doesn’t need no stinking (rebellious ) alumni or their money , apparently wslr.org/new-college-...

New College Foundation dissolves its alumni association - WSLR+FogartyvilleThe board strips the association of their seat and forms a mission-aligned replacement.wslr.org
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Releasing this kind of information two days before a voting AC is a new approach, I think. Kind of puts a damper on the whole procedure. www.statnews.com/2026/07/27/f...

Ahead of hearing, FDA questions the efficacy of Capricor's Duchenne drugAhead of a hearing, the FDA raised questions about the benefits of a Duchenne treatment from Capricor Therapeutics, another twist for the rare disease drug.www.statnews.com
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Well, I suppose I should listen to this, but it sounds painful. No actual molecular entity, and no clear jurisdiction. Another “ spin straw into gold or guess my name” scenario for the FDA. Let the AEs begin… open.substack.com/pub/maggiefo...

This Week’s FDA Committee Hearing on Peptides Was NutsIt’s important to understand how abnormal this all wasopen.substack.com
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The NAS has been trying the “ don’t make waves, play nice approach “ but it looks like short of negating it’s actual role, the time for that approach is over.

Frank Amari

Tonight, he goes after the National Academy of Sciences, regarding climate change:

000

Can things get more disturbing? www.reuters.com/legal/litiga...

Kalshi to allow bets on clinical trials, FDA decisionsPrediction market platform Kalshi will start taking bets on the outcomes of clinical trials and FDA regulatory reviews, it said on ​Thursday, making drug-development odds public for the first time.www.reuters.com
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Well, I am reassured that someone in Congress realized that Makary and Prasad were not obeying FDA rules for good guidance. Rule making is not done by journal editorials. And the new commish seems to understand that too. www.raps.org/resource/dia...

Diamantas backtracks on Makary’s policies issued in journal articleswww.raps.org
020

With the first two OTP ACs in the Trump administration ( yeah, you read that right) coming up, we can only hope so. www.statnews.com/2026/07/15/f...

Under a new leader, the FDA's biologics center moves to steady itself after stormy chapterAfter his predecessor's turbulent tenure, Karim Mikhail is working to restore staff morale and revisit controversial rejections.www.statnews.com
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If you are interested in how much can be predicted by genotype alone, here is an interesting new wrinkle. They are going to have to figure out how to put time in the algorithm.

Wellcome Sanger Institute

Using DNA data from UK birth cohorts, researchers have found that rare DNA changes are most strongly linked to cognition in early childhood, while common DNA changes become more influential as children grow. 🧬 https://bit.ly/4b5w0xh

020

WTF!? Since you can’t access the buildings or most of the parking lots without a gov PIV card that requires a background check, how does this make sense?

AltFDA

Good morning ppl! Fucking ICE has been using an FDA building on our damn campus for part of théir fucking ops. They are also approaching FDA employees in the adjacent parking lots to “verify” who they are. This would be a great protest pop up!!!!

141

Well, good for her, but in relation to the amount of money the Trump family has absconded with since the beginning of this administration, it is chump change. A rounding error.

Mia Farrow

E. Jean Carroll has finally received the $5.6 million the court ordered Trump to pay her for sexual abuse and defamation www.npr.org/2026/07/14/n...

010

FDA regulation of tobacco was always an intricate tap dance. How does the safe and effective agency regulate something that is not safe, and has no legitimate health related action? I watched an agency executive dance through “ deeming” rules, and left puzzled and disturbed. This is more of same.

Kathleen Bachynski

“Leppanen and several scientists told The Examination that the pouches could shed tiny particles during use, which could be absorbed by users. Research on microplastics indicates they accumulate in human organs, and evidence is emerging that this could be harmful.”

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This.

Carl Quintanilla

“.. Strategy is the art of making power matter. The Iran war has shown, unfortunately, that an asymmetry of strategic competence can offset a profound asymmetry of strength.” @opinion.bloomberg.com www.bloomberg.com/opinion/feat...

010

Former Fed here: this article is accurate. Congress has been starving and strangling the Fed workforce through my entire career. Both parties: “ reinventing government “ was a Democratic hit job. To get talented young people to join the Feds after DOGE, you will need to sweeten the deal.

Liberal Currents

"It was easy to wreck because it was hollow. And to merely restore that structure would also restore that structure’s vulnerabilities, ready for another—more intelligent, more competent, more ruthless—authoritarian to deliver the coup de grâce." www.liberalcurrents.com/how-to-rebui...

001

Reading material in the restaurant of my hotel in Montreal- bound copies, no less. This was how I improved my French when I was a teenager. Not that I have much useful French ability anymore. This week will be a trial to both me and my interlocutors.

010

This. Plus man of people, went to GW, then worked for Blackwater. The whole thing seemed full of holes, too good to be true. And apparently, it was. Democrats need to stop looking for political messiahs.

Elizabeth Lopatto

speaking as a metalhead: the guy who hasn't removed his nazi tattoo is not a guy you want to be around. I don't care what he says about how he got it. if he didn't get it covered or lasered, you cannot trust him.

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