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Профиль

Gonçalo Castelo-Branco

Профиль Vively

Professor of Glial Cell Biology @ Karolinska Institutet, Stockholm, Sweden • epigenomics • single-cell • spatial • oligodendrocytes • myelin • multiple sclerosis • 🎧 Hannes • https://ki.se/en/people/goncalo-castelo-branco

Plenary talk at #FENS2026! @fens.org And my soundtrack for the conference was "Dancing with the Europeans" from @suedehq.bsky.social, who gave a fenomenal concert at the Cruilla festival in Barcelona! youtu.be/PCNdb5zlQLE?...

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Join us at the 13th Developing Brains, October 7th, Nobel Forum @ki.se! Register at news.ki.se/calendar/dev... with @anderssonlab.bsky.social @sarabiz86.bsky.social @andreabrandlab.bsky.social among other! @hjerling-leffler.bsky.social @ulrikakmarklund.bsky.social @flallemend.bsky.social

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Come and start your group at @ki.se! ki.se/en/about-ki/...

Assistant Professor recruitment programme 2026Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...ki.se
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Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...

Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs - Nature NeuroscienceSingle-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...www.nature.com
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Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye youtu.be/naKrdCozPUg?...

Google Searchshare.googlechrismlangseth

Let me introduce you to KaroSpace, which is a rapid-access framework for interactive exploration of multi-sample spatial omics data. The preprint can be accessed here: www.biorxiv.org/content/10.6...

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Congrats @patrikernfors.bsky.social!!! Our head of the MolNeuro unit at @ki.se, an inspiration to all of us!

The Brain Prize

Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026

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Curling kick off 2026 of our Molecular Neurobiology unit @ki.se! @hjerling-leffler.bsky.social @onurdagliyan.bsky.social @patrikernfors.bsky.social @matzag.bsky.social @gvolkmer.bsky.social ...and many others!

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A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.

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My 2025 soundtrack, with the music I was listening to for our papers, preprints, etc, including Sonic Surf City's Surfing Santa (by Ola Hermanson)... for Ola. open.spotify.com/playlist/5ts... Happy Xmas and 2026!

Spotify – Web Playeropen.spotify.com
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SciLifeLab PULSE postdoc program, our lab can be one of the hosts!

SciLifeLab

Our call for 27 PULSE #postdocs is OPEN! PhD within the last 3 years looking to grow your life science career? SciLifeLab PULSE (MSCA Cofund) offers 3-year postdoc fellowships at Swedish universities with academic & industry secondments 🧪 🖥️ 🧬 📅 Apply Dec 15, 2025-Mar 16, 2026 👉 bit.ly/3MD7Pwz

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Physiology or Medicine Nobel Lectures 2025 at @ki.se , with the key experiments and notes leading to the Tregs discovery!

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Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com! Check it out at: www.nature.com/articles/s41... with @pkukanja.bsky.social, @deckardw.bsky.social, among others

Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature NeuroscienceSingle-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...www.nature.com
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Our latest, a tour de force from @carlstrom.bsky.social ! And here is my soundtrack for the journey, The Bike Song, by Mark Ronson and The Business Intl, dedicated to Karl's bike! youtu.be/rVELTxKRoHA?...

Mark Ronson, The Business Intl. - The Bike Song (Official Video)YouTube video by MarkRonsonVEVOyoutu.beKarl Carlström

New preprint from @gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes. www.biorxiv.org/content/10.1...

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Join us for the inaugural annual Ernest Arenas Memorial Lecture at the Nobel Forum at @ki.se. with Prof. Roger Barker, University of Cambridge "Repairing the human brain using transplants - is it possible? The story of Parkinson's disease" Tuesday November 25th at 15:00 news.ki.se/calendar/the...

The Ernest Arenas Memorial Lecture: Repairing the human brain using transplants- Is it possible? The story of Parkinson's disease.Welcome to The Ernest Arenas Memorial Lecture with Professor Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge and Consultant Neurologist at Addenbrooke's Hospital.news.ki.se
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Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

Spatial dynamics of brain development and neuroinflammation - NatureA tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.www.nature.com
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Fantastic Gioele!

Gioele La Manno

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

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Developing Brains on!

Gonçalo Castelo-Branco

12th Dev Brains: @junyuecao.bsky.social @alainchedotal.bsky.social @cecilecharrier.bsky.social @trayon.bsky.social Isabel Espinosa-Medina Beatriz Rico Michael Ziller Dwight Bergles news.ki.se/calendar/dev... @hjerling-leffler.bsky.social @ulrikakmarklund.bsky.social @flallemend.bsky.social

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Ana Falcão's lab latest on multi-omics profiling of the Lateral Ventricle Choroid Plexus! @icvs-uminho.bsky.social www.biorxiv.org/content/10.1...

Multi-omics Profiling of the Lateral Ventricle Choroid Plexus Reveals Developmental Cellular Remodeling, Early Immune Gene Activation, and a Novel Epithelial SubtypeHealthy brain development and function highly depend on the choroid plexus. Temporal alterations in the cellular landscape and gene expression of choroid plexus cells can alter immune cell trafficking...www.biorxiv.org
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