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Latest from the lab and a fantastic collaboration with Eric Brown's team at @mcmasteriidr.bsky.social. Screening for new antibiotics from actinomycete extracts under nutrient-deprived conditions identifies a megacluster of synergistic antibiotics that target biotin biosynthesis. rdcu.be/fqejG

A Streptomyces megacluster encodes synergistic biotin-targeting antibioticsNature - In Streptomyces spp., a conserved biosynthetic gene megacluster produces an arsenal of distinct antimicrobials that converge on bacterial biotin biosynthesis as a naturally evolved...rdcu.be

The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first. links.springernature.com/f/a/Q0JMeeZK...

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - NatureImproved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...links.springernature.com

Latest work from PhD student Amna Abbas. One enzyme inactivates three different classes of antibiotics! Yikes. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

The latest from the lab. A new look at an ‘old’ antifungal reveals a novel target with efficacy against MDR fungal pathogens. Nature still has lots to teach us. Great collaboration with the Li, Heitman, and Cowan labs. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

The latest from the lab. A new antifungal lipopeptaibiotic active vs MDR C. auris. rdcu.be/ezVt4

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation libraryNature Communications - In this work, authors utilise a prefractionation natural product extract screening platform, which uncovers coniotins, lipopeptaibiotics with broad antifungal activity and a...rdcu.be

I'll be joining Cassandra Quave this afternoon for a live chat open.substack.com/pub/naturesp...

A New Antibiotic from Nature + Live Science Chat this Friday!Scientists have discovered a new broad-spectrum "lasso peptide" antibiotic.open.substack.com

The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosomeNature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...rdcu.be

Check out this cool video of my McMaster Degroote Infectious Diseases Institute colleague Cameron Curie: youtu.be/jpt9-Dfj6W0?...

Cameron Currie's Ant LabYouTube video by McMaster Universityyoutu.be