Manxman Scientist. Neurobiologist, Group Leader, Interests: ion channels, extreme biology, mole-rats, sensory transduction, touch, pain, social brain, flying www.mdc-berlin.de/lewin
For me this paper is a career highlight..truly astonishing biology! www.nature.com/articles/s41...
A queen odour mediates reproductive suppression in a eusocial mammal - NatureNaked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...www.nature.comwww.nature.com/articles/s41...
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA - Nature CommunicationsThe long-living rodent naked mole-rat has a distinct break in its 28S ribosomal RNA. Here, the authors present cryo-EM structures showing this cleavage is stabilized by surrounding ribosomal proteins,...www.nature.comwww.mdc-berlin.de/news/news/ga... It is a great honour to be elected to the Leopoldina. I am pretty sure I am the first Manxman to be elected to this august body!
Gary Lewin elected new Leopoldina memberCongratulations to Gary Lewin on his election as a new member of the German National Academy of Sciences Leopoldina! The prestigious honor recognizes his scientific accomplishments over the span of hi...www.mdc-berlin.de@mdc-berlin.bsky.social
Looking forward to this!
Felix Viana3 full days of #Mechanobiology in 😎 Alicante Only 5 weeks left! @garyrlewin.bsky.social @embo.org Lecture Information and registration: 𝐡𝐭𝐭𝐩://𝐦𝐞𝐜𝐡𝐚𝐧𝐨𝟐𝟎𝟐𝟔.𝐮𝐦𝐡.𝐞𝐬/ mechano2026@manners.es mechano2026@umh.es #Piezochannels #IonChannels #Mechanosensation #Hearing #Integrins #Wound_repair
@mdc-berlin.bsky.social Excited to see our paper with Sam @amapruns.bsky.social and Fabian Coscia now published. www.nature.com/articles/s41...
Properly published! Mechanosensitive currents in sensory neurons lacking PIEZO2 www.cell.com/biophysj/ful...
Published! Check out our latest work on sensory mechanotransduction. PIezo2 gene deletion barely impacts mechanically-activated currents in mouse sensory neurons. Is the cell body a good model for in vivo transduction? www.cell.com/biophysj/pdf...
www.cell.comWe were very happy to help, in a very small way, in getting this beautiful structure out. The structure is remarkably conserved considering the famous 28S ribosomal RNA split. I suspect that the split has as yet unknown biological repercussions in this remarkable animal..
Misha KudryashevWe have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity. Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look. www.biorxiv.org/content/10.1...
Check out this new paper from Stefan Lechner's lab showing with minflux nanoscopy how PIEZO1 channels cluster and invagininate the membrane. Glad we could make a small contribution to this nice story! www.science.org/doi/full/10....
Cluster nanoarchitecture and structural diversity of PIEZO1 at rest and during activation in intact cellsMINFLUX nanoscopy reveals subcellular distribution and conformational diversity of PIEZO1 channels in intact cells.www.science.orgSam has now started her new group at the Helmholtz Center for Infection Research Diseases. Congratulations! I wish her the very best for her independent career. The time Sam spent with us was hugely successful in many respects and we will all be sad to see her go..
Sampurna ChakrabartiDelighted to be starting a new research group at @helmholtzhzi.bsky.social ! Happy to chat about working together! #pain #infection #electrophysiology www.helmholtz-hzi.de/en/research/...
Widely accepted findings should be validated. For example, mechanically-activated currents (MA-currents) in sensory neurons depend on PIEZO2..right?. Here we show that PIEZO2 is NOT associated with a huge loss of MA-currents in sensory neurons. #ion channels #sensory www.biorxiv.org/content/10.1...
Mechanically-gated currents in mouse sensory neurons lacking PIEZO2Touch sensation starts with the opening of mechanically-gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low threshold mechanoreceptor...www.biorxiv.orgbbc.com/news/article... I worked as a tram driver for two summers with this fella (nearly 40 years ago!)...he is right, best job I ever had
Driver celebrates 'unbelievably unique' 50-year horse tram careerTram driver Peter Cannon is celebrating half a century working on the Douglas Bay Horse Tramway.bbc.comRead about how a book about extraordinary animals with Russ Hodge and Kat Menschik came to be. www.stiftung-charite.de/en/our-fundi....
www.stiftung-charite.deProud to a part of this great study from the lab of Annette Hammes. A new role for mechanosensitive PIEZO2 channels in the development of the coronary arteries. www.nature.com/articles/s44...
physoc.onlinelibrary.wiley.com/doi/full/10.... Our latest paper is now published, open access of course. Check it out! Mechanotransduction and regeneration! More to come soon..
The mechanotransduction protein STOML3 is required for proprioceptor plasticity following peripheral nerve regenerationNerve regeneration is associated with the plasticity of sensory neurons such that even muscle afferents directed to the skin form mechanosensitive receptive fields appropriate for the new target. STO...physoc.onlinelibrary.wiley.com