Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org Fast-fair-transparent / Open Access / Open Science
Redefining ecological opportunity for evolution in the Anthropocene: Lutz Becks, @reefgenomics.bsky.social and colleagues comment on the concept of timescale mismatch between the rates of environmental changes and evolutionary processes link.springer.com/article/10.1...
NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice Shigeki Miyamoto, Demin Wang and collaborators link.springer.com/article/10.1...
NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice - The EMBO JournalOxidative stress and genotoxic damage activate NF-κB signaling through intracellular pathways distinct from those initiated by membrane receptors. DNA damage selectively induces post-translational mod...link.springer.comCentrosome assembly is triggered by relief of autoinhibition – @jordanraff.bsky.social, @hymanlab.bsky.social, @smlea.bsky.social et al now show Polo/PLK1 phosphorylation unlocks Centrosomin/Cnn scaffolding in a conserved mechanism for mitotic centrosome maturation link.springer.com/article/10.1...
Polo/PLK1 phosphorylation relieves Centrosomin/Cnn autoinhibition to promote centrosome scaffold assembly - The EMBO JournalMitotic centrosome maturation requires Polo/PLK1-dependent expansion of the pericentriolar material (PCM). In Drosophila, Centrosomin (Cnn) assembles a scaffold around mitotic centrioles through inter...link.springer.comRole of membrane-organizing SPFH proteins in plants: @hannah-web.bsky.social, Alexandra Ehinger, @birgitkemmerling.bsky.social et al define how Arabidopsis HIR2 forms higher-order assemblies and organizes receptor signaling domains link.springer.com/article/10.1...
The Arabidopsis SPFH protein HIR2 modulates receptor signaling and plasma membrane organization - The EMBO JournalPlant plasma membrane proteins are organized into distinct domains; however, the principles that govern this spatial organization are not fully understood. HYPERSENSITIVE-INDUCED REACTION (HIR) protei...link.springer.comLooking for weekend reading? New review by @kei-jokura.bsky.social and @jekely.biologists.social.ap.brid.gy revisits nerve nets, their functional organization, and evolutionary implications link.springer.com/article/10.1...
rDNA-break-induced RAD54L delocalization to nucleolar caps is important for efficient homologous recombination repair and nucleolar DNA damage responses @elainesanij.bsky.social and collaborators link.springer.com/article/10.1...
RAD54L coordinates the nucleolar DNA damage response to maintain rDNA stability - The EMBO JournalThe nucleolus is organized around actively transcribed ribosomal RNA genes (rDNA), where high RNA polymerase I (Pol I) activity creates intrinsic susceptibility to replication stress and DNA damage. H...link.springer.comTripartite ER-mitochondria-lipid droplets contact sites control adipocyte metabolic flexibility Marie Palard et al. link.springer.com/article/10.1...
Tripartite ER-mitochondria-lipid droplets contact sites control adipocyte metabolic flexibility - The EMBO JournalAdipocyte dysfunction is a major driver of obesity-associated cardiometabolic disease, underscoring the need to understand how lipid storage and mobilization are regulated and disrupted. The ER-anchor...link.springer.comFUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5 Gina Picchiarelli, @annewienand.bsky.social et al link.springer.com/article/10.1...
FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5 - The EMBO JournalFUS is an RNA-binding protein mutated in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive muscle weakness. We show in this work that a heterozygous knock-i...link.springer.comProteolytic activation of executioner caspase-3 and -7 regulates different physiological processes in mice Melanie Fritsch, Hamid Kashkar and coworkers link.springer.com/article/10.1...
Proteolytic activation of executioner caspase-3 and -7 regulates different physiological processes in mice - The EMBO JournalCaspase-3 (CASP3) and caspase-7 (CASP7) are the two major executioner caspases that are proteolytically activated by upstream initiator caspases. They possess almost indistinguishable activity, which ...link.springer.comYeast dynamin Vps1 coordinates cycles of membrane constriction and relaxation by coupling GTP hydrolysis, to scaffold membrane remodelling during retrograde trafficking Thomas Pucadyil and coworkers link.springer.com/article/10.1...
Vps1 drives membrane constriction and fission necessary for endosomal protein sorting - The EMBO JournalThe trafficking of cargo between endosomes and the Golgi apparatus uses both retromer-dependent and retromer-independent routes. Disruptions to these routes lead to the mis-sorting of lysosomal cargo,...link.springer.comWhat prevents premature fusion of Atg9 vesicles en route to autophagosome formation sites? Hitoshi Nakatogawa and collaborators show that Atg23 prevents aberrant SNARE-dependent fusion until being releases upon Atg9 phosphorylation by master initiator Atg1 link.springer.com/article/10.1...
Atg23 prevents aberrant fusion of Atg9 vesicles during delivery to autophagosome formation sites - The EMBO JournalAutophagosome biogenesis depends on the accurate delivery of membrane lipids to the pre-autophagosomal structure. Golgi/endosome-derived Atg9 vesicles provide the membrane seed for this process, but h...link.springer.comHow does the gut epithelium respond to pathological oxidative stress? Nan Gao and collaborators find that ROS stimulate Paneth cell de-differentiation and reduce their production of anti-microbial peptides link.springer.com/article/10.1...
Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function - The EMBO JournalThe gut epithelium faces constant environmental oxidative stresses. How it responds to pathological reactive oxygen species (ROS) is not fully understood. Using Paneth cell (PC) lineage reporters and ...link.springer.comDevelopmental priming of adult proteostasis and longevity by NuA4 complex activity in early life Lianfeng Wu and colleagues link.springer.com/article/10.1...
Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life - The EMBO JournalProteostasis collapse, a hallmark of aging and neurodegeneration like Alzheimer’s disease (AD), causes irreversible damage in late life. Whether late-life proteostasis capacity is developmentally prog...link.springer.comMetabolic buffering restricts phenotype switching in melanoma Custodia García-Jiménez, @achocarro-calvo.bsky.social and coworkers link.springer.com/article/10.1...
Metabolic buffering restricts phenotype switching in melanoma - The EMBO JournalThe impact of the metabolic microenvironment on epigenetically plastic cancer cells underpins phenotypic heterogeneity, a major cause of metastasis and therapy resistance. Nutrient limitation is a key...link.springer.comCostimulatory TNFRs signal not only through TRAF-binding motifs, but also through membrane anchoring: Jiali Zhu, Xi Xu et al identify a juxtamembrane motif in immunoreceptors like OX40 that organizes lipid engagement & TRAF2 recruitment for robust NF-κB activation link.springer.com/article/10.1...
A conserved basic motif mediates membrane anchoring and TRAF2 recruitment across costimulatory TNFRs - The EMBO JournalCostimulatory receptors of the TNFR superfamily are key components in synthetic immunoreceptors, yet how their intracellular domains coordinate membrane anchoring with adaptor recruitment remains unre...link.springer.comISSUE 14: Review on skin aging SPACA9 and MNMIP1 on spermatid manchette microtubules DNA damage-activated kinase in bacterial immunity MORC3 regulates interferon via tandem repeat enhancer Cover: Sekler, Shirihai and coworkers link.springer.com/journal/4431...
Targeting oncogenic KRAS in pancreatic cancer: Raghu Kalluri and colleagues implicated tumor microenvironment remodeling by mediator kinase CDK8 in resistance development and as potential new vulnerability link.springer.com/article/10.1...
CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC - The EMBO JournalMutations in KRAS are a dominant driver of pancreatic ductal adenocarcinoma (PDAC), with about 50% of patients presenting with KRASG12D mutations. Small molecule inhibitors targeting KRASG12D suppress...link.springer.comR2HaPpY: Judit Villen and colleagues present a new method overcoming the need for labor-intensive protocols and costly enrichment reagents in large-scale tyrosine phosphoproteomics studies, and report the deepest phosphotyrosine dataset of EGF signaling yet link.springer.com/article/10.1...
Scalable phosphotyrosine enrichment with SH2 superbinder enables deep profiling of EGF responses - The EMBO JournalPhosphotyrosine signaling plays a critical role in many biological processes, from cell proliferation to immune response. Despite its importance, proteomic studies of tyrosine phosphorylation have bee...link.springer.comCoordination of nutrient and growth signals: @hietakangaslab.bsky.social identities transcription factor Spalt-related/SALL1 as ISR-activated inhibitor of growth and lipid storage, counteracting FoxO link.springer.com/article/10.1...
Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response - The EMBO JournalAnabolic and catabolic processes are coordinated by a conserved regulatory network, which includes the nutrient-sensing protein kinase mTOR complex 1 (mTORC1) and the insulin- and stress-responsive tr...link.springer.comHow do tissue properties influence mitotic spindle assembly & chromosome segregation in non-cell-autonomous ways? V Marthiens, R Basto et al show neural stem cells sense mechanical forces imposed by cell density via cortical actin & microtubule depolymerase activity link.springer.com/article/10.1...
Mechanical constraints regulate embryonic stem cell mitosis in the developing brain - The EMBO JournalResearch on mitosis has predominantly examined cell-autonomous mechanisms, yet its regulation and consequences within the broader physiological context remain largely unexplored. It remains, therefore...link.springer.com