Профиль

Interested in autoinflammatory diseases? Read our review on Variants of Uncertain Significance (VUS) in @natrevrheum.nature.com with @alessandracarbone.bsky.social, Guilaine Boursier & Sinisa Savic. How to decode VUS through genetic, in silico, functional approaches and clinic! rdcu.be/fkOJM

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO ReportsIRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...link.springer.com

📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon. Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social @labxc.bsky.social Anti-phage Immunity, Horizontal gene/ MGE transfer 📚 Teaching at ENS de Lyon within the Department of Biology.

"Don’t mourn his loss—be grateful that you knew him". Bacteriologist at Pasteur then at INEM, Alain Charbit spent most of his career working on Intracellular bacteria and notably Francisella tularensis to decipher the role of its metabolism in virulence. He was a colleague and a friend.

Here is the latest paper of the lab @ciri-lyon.bsky.social on the pyrin #inflammasome, the MEFV gene variants and the associated autoinflammatory diseases, Familial Mediteranean fever (FMF) and PAAND.

Another link between RHO GTPases and inflammasomes. RAC2 GoF variants activate the NLRP3 inflammasome, Congrats to the Boyer group @lauboye.bsky.social! bsky.app/profile/jem....