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A bit late but…Tenured! Immense gratitude for those who got us here. Firstly the students/postdocs (too many to list!) who took a chance on an unproven lab and were unafraid to pursue some strange new ideas. I couldn't have predicted our path, and I couldn’t be more excited for what's next.

#CellSigSRC

Missed the deadline to submit an abstract to #FASEB Dynamics and Encoding in Cell Signaling (June 21-25)? Fear not: abstract deadline has been extended for 1 more week, until *Sunday May 10*. Several speaker slots and travel awards remain! events.faseb.org/event/Dynami... #CellSigSRC

Abstracts are due this Sunday, April 26th! ⏰ Come present your latest work to a fantastic community of researchers interested in all aspects of how cell signal dynamics regulate biological function. events.faseb.org/event/Dynami...

Abstracts due in 2 weeks for the Signal Dynamics FASEB! Many speaking slots will be filled from submitted abstracts events.faseb.org/event/Dynami...

The Hughes lab @hugheslabpenn.bsky.social develops a robust optogenetic RET receptor and shows it can drive shape changes characteristic of kidney development. Will be exciting to see how opto can help us comprehend development of complex tissue structures

Abstract submission now open for the Signaling Dynamics FASEB in Nashville (6/21-25, 2026)! events.faseb.org/event/Dynami... Many speaking slots from submitted abstracts, with a focus on emerging work from trainees and early-career. Come for the science, stay for the line dancing.

Now in print at ACS Synbio! Introducing Aviatar: a concept for inducible translocation to any cell compartment using only a 1-component probe pubs.acs.org/doi/10.1021/...

Optogenetic Translocation to Subcellular Compartments through Regulation of Protein AvidityInducible translocation to subcellular compartments is a common strategy for protein switches that control a variety of cell behaviors. However, existing switches achieve translocation through induced...pubs.acs.org

Speaker lineup posted for FASEB: Dynamics and Encoding in Cell Signaling (June 2026)! Live-cell imaging, biosensors, signal dynamics, and quant. modeling/analysis, across the biosciences. Stellar lineup, Keynotes from Tobias Meyer and Jin Zhang Join us in Nashville! tinyurl.com/bd9wmyve

🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇

🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

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🤩🤯 work by @hugheslabpenn.bsky.social: cyclic mechanics entrain proper dev’t timing/patterning in the kidney. Super innovative concepts and approach, congrats all!!

#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!

#CellBio2025 come check out the workshop on applying optogenetic tools in cell biology! Today (Sunday) at 5:30p in Rm 121. Note that this session does *not* appear in the app for some reason

Last day to apply!

Explore how synthetic & systems biology can advance our understanding of cancer initiation at NCI’s virtual S³ Innovation Lab! Synthetic biologists particularly encouraged to apply! Application deadline now June 5: apply.knowinnovation.com/s3-cancer-in...