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Профиль

Antigen Evolution & Design Lab

Профиль Vively

We study how pathogen antigen proteins evolve and use this knowledge to improve how we design vaccines and therapeutics 💻 💉 🧬 @pasteur.fr 🇫🇷 Lab Head 🧑‍🦱 @spyroslytras.bsky.social https://research.pasteur.fr/en/team/antigen-evolution-and-design/

Delighted to be involved in this recent preprint led by our friends at @cvrinfo.bsky.social @cvrbioinfo.bsky.social @davidlrobertson.bsky.social Protein language models learn underlying mutation biases alongside fitness landscapes www.biorxiv.org/content/10.6...

Protein language models learn underlying mutation biases alongside fitness landscapesProtein language models (PLMs) score the effects of amino acid replacements as pseudo-probabilities, which are widely utilised to map protein fitness landscapes. However, because their training data r...www.biorxiv.org
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🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st

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First paper with the lab's affiliation!! ✨✨ summarising some of the cool concepts that the Antigen Evolution & Design Lab will be working on! Together with amazing collaborators @mghafari.bsky.social and @grovearmada.bsky.social www.annualreviews.org/content/jour...

Studying the Deep Evolution of Viruses in the Era of Artificial Intelligence Structure PredictionHigh mutation rates erode viral sequence similarity, obscuring deep evolutionary history. While protein structure is far more conserved than sequence, its use in evolutionary studies has historically ...www.annualreviews.org
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Inaugural post! We are a brand new lab @pasteur.fr studying how pathogen antigens evolve and how we can exploit these proteins' evolution to make better vaccines! Read a few words from the currently sole member of the lab @spyroslytras.bsky.social below! 😁 www.pasteur.fr/en/research-...

Predicting viral evolution with AISpyros Lytras is one of four young scientists selected in 2025 to lead new research groups at the Institut Pasteur. He has headed the “Antigen Evolution & Design laboratory” 5-year Group (G5) since Ju...www.pasteur.fr