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Take a look at this new preprint led by @fanny-wodrascka.bsky.social on tension-driven cell extrusion! Using optogenetics, she studied how tensile stresses can influence fate (alive or dead) and direction (apical or basal) of extruded cells. Happy to have contributed a bit to this nice story!

Mechanical Tension Actively Triggers RhoA-Mediated Cell ExtrusionCell extrusion is a fundamental process in tissue homeostasis, morphogenesis, and cancer progression, facilitating the removal of cells either alive or through apoptosis. While biochemical signaling p...www.biorxiv.org

Happy to share our new review on biophysical principles of cell competition and elimination: www.cell.com/trends/cell-... With @bladoux.bsky.social and @rmmege.bsky.social, we discuss mechanical fitness, how loser cells are removed through various strategies and how forces can effect their fate

Are you investigating cell tissues and interested in stress patterns? TFM + BISM reveals them! 👇 With @luanger.bsky.social and P. Marcq, we summarise the applicability across different exp. conditions regularly used in the @bladoux.bsky.social @rmmege.bsky.social lab. Full pipeline on Lucas GitHub!

Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...

Excited for my thesis defence, join us for a discussion on the role of mechanical forces in building and maintaining epithelial tissues if you happen to be in Paris in September!