Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
Trade-offs Between Intergenerational and Transgenerational Effects: experimental data and demographic simulation model of multigenerational trade-offs in evolution: academic.oup.com/evlett/advan...
Evolutionary trade-offs between intergenerational and transgenerational fitness effectsAbstract. Intergenerational and transgenerational fitness effects can shape evolutionary processes. Theoretically, however, intergenerational and transgeneacademic.oup.comwww.nature.com/articles/s43...
Modulating IL-11-dependent matrix stiffness to delay ovarian aging - Nature AgingThe ovarian stroma becomes increasingly stiff with age, impairing ovarian function. The mechanisms that underlie this process are only partly understood. Here, the authors show that IL-11, which is el...www.nature.comReactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science www.science.org/doi/10.1126/...
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switchMammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...www.science.orgJob advert! There is microbiology lectureship at @biouea.bsky.social with a focus on non-academic impact: vacancies.uea.ac.uk/vacancies/20...
Impact Lecturer in Microbiology (ATR1737) in University of East Anglia | UEAView details and apply for this Impact Lecturer in Microbiology (ATR1737) vacancy in University of East Anglia. Faculty of Science
School of Biological Sciences
Impact Lecturer in Microbiology...vacancies.uea.ac.ukAn antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan Great first post by @itamarh.bsky.social 😀 Very happy to contribute to this cool study!
Itamar Harel1/6) What if aging begins, in part, as a bargain made in youth? In turquoise killifish, editing vgll3—a gene linked to puberty-timing in humans and salmon—revealed one of the first causal single-gene examples of antagonistic pleiotropy in vertebrate aging 🧵
Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy IndividualsSupplement users have lower epigenetic biological age than non-users. Several supplements or supplement classes are associated with some benefit on epigenetic age in either cross-sectional or longitu...doi.orgExcellent paper with very clear and important results - selection on relative egg size (maternal investement) reduces lifespan and accelerates ageing in females.
Barbara TschirrenNew paper out: Artificial selection for increased reproductive effort accelerates actuarial senescence and reduces lifespan in a precocial bird url: royalsocietypublishing.org/rspb/article... @uniexecec.bsky.social @erikpostma.bsky.social @joelpick.bsky.social y.social @oscarvedder.bsky.social
journals.plos.org/plosbiology/...
Translocation of bacteria from the gut to the brain in miceRecent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial transloc...journals.plos.orgjournals.plos.org/plosbiology/...
Impacts of parental age and inbreeding on fitness in a wild insectParental age and inbreeding have substantial fitness effects in animals both in nature and lab conditions, and can change with temperature, but how these factors affect fitness in insects remain uncle...journals.plos.org
