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Axon initial segment plasticity in neuronal circuit function and memory formation www.sciencedirect.com/science/arti...

Axon initial segment plasticity in neuronal circuit function and memory formationAxon initial segments are the site of action potential initiation and the final site of synaptic integration. Since the seminal discoveries by Grubb &…www.sciencedirect.com

Told ya ⭐⭐

The last time Spain reached a World Cup final, I was living in Canada. Fast-forward to 2026: they’re in the final again, and I’m living in the UK. At this point, it’s less of a coincidence and more of a national duty for me to stay away from Spain. I’m a jinx to my own country. ¡De nada! 🇪🇸

Just so you have an idea of how my day is going

“Crossing barriers at the axon initial segment” comes to Edinburgh, 7–8 Dec 2026. A fantastic line-up covering AIS structure, function, plasticity and disease, plus posters and discussions. Free to attend, with wintry Edinburgh as the backdrop 😉 Details below! royalsociety.org/science-even...

Crossing barriers at the axon initial segment | Royal SocietyTheo Murphy meeting organised by Professor Matthew Grubb, Professor Maren Engelhardt and Professor Maarten H P Koleroyalsociety.org

We're so close, folks

I hadn’t realised this wasn’t open access and have received a few emails asking for the PDF. If that’s also you, please feel free to reach out - happy to send it over!

Couldn’t be prouder of Lauren for presenting her first poster ever at FENS - 6 months in the lab and already presenting and defending the project like a pro! Thank you so much to everyone who kept us busy beyond the end of the poster session - we’re super excited about the feedback 🧠

It’s now! Come over to #317 to chat about mitral cells! 😁

It was a pleasure to discuss the fascinating work of Schamiloglu and colleagues in this Journal Club piece. Turns out that layer 5 pyramidal neuron subtypes defined by dopamine receptor expression exhibit *remarkably* different dendritic integration strategies! www.jneurosci.org/content/46/2...

The Dendrites Decide: Divergent Computation Strategies Define Prefrontal Layer 5 Pyramidal SubtypesThe brain contains a remarkable diversity of neuronal cell types, whose functional roles are shaped by differences in molecular identity, morphology, connectivity, and intrinsic electrophysiological p...www.jneurosci.org

FENS, we’re coming! Super excited about this one, plus we get to enjoy the Mediterranean summer?! 🧠☀️

Captured this beauty last night at the confocal 🔴virally-driven tdTomato labelling mitral cells 💠 nuclear staining

They forgot to annotate the Y axis

Sunday on the grind preparing everything for our FENS adventure. If you're going, come to our poster (or at any other time, really) and say hi! We'll be presenting on the 9th in the afternoon session. Potential fresh data coming through as well...stay tuned!🧠 @fens.org

'Our results identify a mechanism for cortical excitatory and inhibitory neurogenesis involving SCN2A, and reveal that early neurogenesis deficits precede postnatal neural circuit dysfunction in SCN2A-associated disorders' www.biorxiv.org/content/10.1...

The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesisVoltage-gated sodium channels regulate neuronal excitability and synaptic transmission in the postnatal and adult brain. The gene SCN2A , encoding the sodium channel Nav1.2, regulates synaptic develop...www.biorxiv.org

GluN3A Is Required for Coordinated Postnatal Development of Axonal and Dendritic Branching Patterns in Mouse L2/3 Callosal Projection Neurons www.jneurosci.org/content/46/2...

GluN3A Is Required for Coordinated Postnatal Development of Axonal and Dendritic Branching Patterns in Mouse L2/3 Callosal Projection NeuronsCallosal projections connect both cortical hemispheres via the corpus callosum, allowing bilateral integration of sensory information. Callosal axons originate mainly from layer (L)2/3 pyramidal neuro...www.jneurosci.org

My niece, 5-yo, first time visiting the UK (London specifically): why does everyone speak English here?

The slow descent to madness in our office

Not even 5 years living in the UK and I’ve already seen 4 Prime Ministers. Bring back the lettuce.