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🔥🔥IDSA AMR Guidance 2026🔥🔥 🔺Notable Updates from the 2024 IDSA AMR Guidance Document 🔺Meropenem dosing update: individualized dosing approach (1–2 g IV q8h) with higher doses considered in selected clinical scenarios. #idsky www.idsociety.org/practice-gui...

🔥 Update 🔥 The IDSA AMR Guidance 2026 link is now back online. You can access the guidance through the original link below. I'll be sharing the Notable Updates from the 2024 IDSA AMR Guidance Document soon. #idsky

🆕🔥🔴ISLEND-1 RCT Among persons with virologically suppressed HIV-1, once-weekly oral Islatravir–Lenacapavir was noninferior to once-daily oral bictegravir emtricitabine tenofovir alafenamide B/F/TAF in maintaining HIV viral load suppression #IDsky #hivsky www.nejm.org/doi/full/10....

Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment | NEJMOnce-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); however, challenges to adherence continue to limit effective treatment....www.nejm.org

Update: The original link appears to be temporarily unavailable. I'll share the updated official link once it's available. #idsky

🔥🔥Just published 🔥🔥 IDSA AMR Guidance 2026 IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections 🔺ESBL , AmpC Enterobacterales 🔺CRE 🔺DTR P. aeruginosa 🔺CRAB 🔺Stenotrophomonas maltophilia #idsky www.idsociety.org/practice-gui...

A thoughtful editorial Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia? #idsky academic.oup.com/cid/article-...

Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia?Yonas Martin, Steven Tong; Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia?, Clinical Infecacademic.oup.com

Staphylococcus aureus bacteremia guidelines recommend obtaining FUBCs every 2-4 days until bacteremia clearance! 🆕💥💥🟢 cohort study: Routine serial follow-up blood cultures after a negative result within 48 hours of MSSA bacteremia: low yield, high cost #idsky academic.oup.com/cid/article/...

Routine serial follow-up blood cultures after a negative result within 48 hours of methicillin-susceptible Staphylococcus aureus bacteremia: low yield, high costEarly skip phenomenon in Staphylococcus aureus bacteremia is rare (3.1%) with a very low risk of missed persistent bacteremia (1%). A practical day-2 focusacademic.oup.com

🆕💥🟢Among 305 episodes with suspected infective endocarditis and valve strands the majority did not represent IE. Recurrence of IE due to the same microorganism within one year was significantly more frequent among episodes with IE compared to those without #idsky academic.oup.com/cid/article/...

How would you describe target trial emulation in two words only? #idsky

Wow! 🆕🔥🔴Multicenter OL NI RCT Oral fosfomycin (3 g once daily) was noninferior to continued intravenous therapy with carbapenems or BLBLIs when used as oral transition therapy for complicated UTIs caused by ESBL-producing Enterobacterales #IDSky #utisky academic.oup.com/cid/article-...

Fosfomycin as Oral Transition Therapy Versus Continued Intravenous β-Lactams for Complicated Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase–Producing Enterobacterales: A Multicenter,...Switching from intravenous antibiotics to oral fosfomycin was noninferior to continuing intravenous therapy for complicated urinary tract infections causedacademic.oup.com

🔥Just approved 🔥 The FDA has approved Utebzi (tebipenem pivoxil) tablets as the first oral carbapenem therapy for adults with complicated urinary tract infections, including pyelonephritis #idsky #EMIMCC www.fda.gov/drugs/news-e...

FDA approves first oral carbapenem therapy for complicated urinary traFDA approves first oral carbapenem therapy for complicated urinary tract infectionswww.fda.gov

🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia | NEJMStaphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...www.nejm.org

While some may view ARISE-FLUIDS as final blow to 30 mL/kg, a new cohort JAMA of 25k pts:initial administration of ≥30 mL/kg associated with lower 30d mortality among pts with hypoperfusion or intermediate lactate elevation w/o severe cardiac or kidney comorbidities. jamanetwork.com/journals/jam...

Comorbidities, Weight-Based Initial Fluid Resuscitation, and Sepsis MortalityThis cohort study evaluates whether administration of 30 mL/kg or more of fluid within 6 hours of hospital arrival is associated with reduced 30-day mortality in adults with community-onset sepsis.jamanetwork.com

🆕💥🔴Multicenter retrospective study of ICU patients with pneumonia BIOFIRE® PN Panel implementation was associated with improved early antimicrobial de-escalation and appropriate therapy #idsky academic.oup.com/cid/article-...

Clinical Impact of the BIOFIRE® FILMARRAY® Pneumonia Panel in the Veterans Affairs Healthcare System: A Difference-in-Differences StudyIn this national, multicenter retrospective study of intensive care unit patients with pneumonia in Veterans Health Administration hospitals, BIOFIRE® PN Pacademic.oup.com

🆕💥🟢Multicenter prospective study shows that quantitative PCR on oral wash has a better positive predictive value than PCR on bronchoalveolar lavage for the diagnosis of Pneumocystis pneumonia in HIV-negative immunocompromised patients #idsky academic.oup.com/cid/article/...

Oral Wash PCR Improves the Diagnosis of Pneumocystis Pneumonia in Immunocompromised Patients Without HIV: A Prospective Multicenter StudyThis multicenter prospective study shows that quantitative PCR on oral wash has a better positive predictive value than PCR on bronchoalveolar lavage for tacademic.oup.com

🔥The ARISE FLUIDS RCT Among adults with septic shock, Restricted fluids + early vasopressors did not result in more days alive & out of the hospital through day 90 than liberal fluids + later vasopressors Pulmonary edema (0.6% in the vasopressor group vs. 5.0% in the fluids group; P<0.001). #idsky

High-Dose Vitamin C in Burns Time to Stop 🆕🔥🟢VICTORY RCT High-dose intravenous vitamin C did not reduce mortality and organ dysfunction and may be associated with harm in patients with severe burn injury #EMIMCC jamanetwork.com/journals/jam...

High-Dose Intravenous Vitamin C in Severe Burn InjuryThis international randomized clinical trial evaluates the efficacy of high-dose intravenous vitamin C in reducing 28-day mortality and persistent organ dysfunction (dependence on mechanical ventilati...jamanetwork.com

For years, the need for longer durations in immunocompromised patients was treated as the exception to every shorter-duration bacteremia discussion. BALANCE may have finally put that belief to rest. Dogma continues to lose ground. #idsky

🆕🔥🟢Post hoc subgroup analysis of the BALANCE RCT 7 Vs 14d duration of antibiotic therapy for bacteremia in immune compromised hosts 1037 immune compromised patients #idsky www.clinicalmicrobiologyandinfection.org/article/S119...

🆕💥🟢Retrospective observational study Anti-MRSA Cephalosporins + Daptomycin as Initial Therapy for MRSA Bacteremia: Does a “Hit Hard and Fast” Strategy Improve Outcomes? #idxposts #DOOR #idsky academic.oup.com/cid/article/...