Подтвердите e-mail

Для публикаций, комментариев, реакций и сообщений подтвердите адрес.

←

Публикация

IOB - Institute of Molecular and Clinical Ophthalmology Basel

👁️ What keeps vision cells alive? A new study just published in Neuron (S. Spirig, @alvaroherreronav.bsky.social et al.) screened 2,700+ compounds across 20,000 lab grown human retinas to find out. 🧵👇

Обсуждение

1 прямых ответов · 5 сообщений

IOB - Institute of Molecular and Clinical Ophthalmology Basel

🔬 The focus: cone photoreceptors. These cells allow us to read, recognize faces, and see colours. When they die, central vision is lost. Despite decades of research, there are still no therapies to stop this process.

Ответ для IOB - Institute of Molecular and Clinical Ophthalmology Basel
Ответ для IOB - Institute of Molecular and Clinical Ophthalmology Basel
IOB - Institute of Molecular and Clinical Ophthalmology Basel

💡 What they found: • Some compounds harm vision cells, revealing safety risks early • Several molecules protect cone photoreceptors • Inhibiting casein kinase 1 is a key protective mechanism

Ответ для IOB - Institute of Molecular and Clinical Ophthalmology Basel
IOB - Institute of Molecular and Clinical Ophthalmology Basel

✨ The full dataset is openly available, including compounds, targets, and effects. 🔗 www.cell.com/neuron/fullt...

Cell-type-focused compound screen in human organoids reveals CK1 inhibition protects cone photoreceptors from deathSpirig, Herrero-Navarro, et al. performed a compound screen in 20,000 human retinal organoids to identify cone photoreceptor damaging and protecting pathways. They identify cone toxicity from HDAC I/I...www.cell.com
Ответ для IOB - Institute of Molecular and Clinical Ophthalmology Basel
IOB - Institute of Molecular and Clinical Ophthalmology Basel

🌍 This gives researchers worldwide a powerful starting point to develop therapies to preserve vision. #AcademicBlueSky #VisionResearch #Ophthalmology #OpenScience #DrugDiscovery #Organoids #Retina #Neuroprotection