Daedalus. He destroyed everyone he crossed paths with. He killed his own nephew. He built a prison to hide a deformed child. He manipulated women to kill Minos. In some versions his whole family is killed as a result of all of it.
moby dickgirlI wish I knew my history better because I can't think of any particular ancient guy who's particularly vile who's not also so incredibly well known that the rest of the 1,000 would also pick him