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Charlotte Houldcroft

I'm pleased to share a preprint today, paper 2/3 of a trilogy (you'll have to wait for the Return of the Jedi). In 2021-22, lots of countries saw unprecedented transmission of enteric adenovirus F41 in children. There were lots of hypotheses about what caused this. www.biorxiv.org/content/10.1...

Viral Diversity Influences T Cell Responses to Enteric Human Adenoviruses F40 and F41Background Human enteric species F adenoviruses are a leading cause of diarrhoea-associated paediatric morbidity and mortality worldwide. The cellular immune response (antigen-specific cytotoxic T cel...www.biorxiv.org
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Charlotte Houldcroft

Data from lots of groups, including mine, looked at one hypothesis: was there a new strain of F41 circulating? Not really - the most severe cases of enteric adenovirus were scattered among strains present in the UK pre and post 2020. www.microbiologyresearch.org/content/jour...

Multiplex MinION sequencing suggests enteric adenovirus F41 genetic diversity comparable to pre-COVID-19 eraHuman adenovirus F41 causes acute gastroenteritis in children, and has recently been associated with an apparent increase in paediatric hepatitis of unknown aetiology in the UK, with further cases rep...www.microbiologyresearch.org
Ответ для Charlotte Houldcroft
Charlotte Houldcroft

A second hypothesis - could F41 have acquired increased immune evasiveness over time? This preprint looks at the T cell aspect of this. www.biorxiv.org/content/10.1... With colleagues in Kenya, we looked at how epitopes have changed since F41 was first isolated in the 1970s (in Holland).

Viral Diversity Influences T Cell Responses to Enteric Human Adenoviruses F40 and F41Background Human enteric species F adenoviruses are a leading cause of diarrhoea-associated paediatric morbidity and mortality worldwide. The cellular immune response (antigen-specific cytotoxic T cel...www.biorxiv.org