Nicotine biosynthesis is completed by cryptic activating glucosylation. Very excited to share the first publication from my PhD, published in @natcomms.nature.com reconstructing the critical ring coupling reaction in a four enzyme one-pot biocatalytic cascade! www.nature.com/articles/s41...

Nicotine biosynthesis is completed by cryptic activating glucosylation - Nature CommunicationsDespite the significance of nicotine, a neuroactive alkaloid produced by tobacco, its biosynthesis has remained elusive. Here, the authors report the in vitro and in planta reconstruction of a fo...www.nature.com