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Публикация

H
heidiklumpe

The preprint from my work @mokhalil.bsky.social and Mary Dunlop's groups at BU is out on bioRxiv! As new tools come online to engineer multicellularity, we asked: how does sticking cells together into larger groups affect their fitness and function?

Обсуждение

Ответы

Ché Pillay

Nice work!

H
heidiklumpe

To explore this, we generated “synthetic flocs” by introducing a single yeast adhesion protein. By comparison with a unicellular control, we could detect costs (e.g., growth defects in rich media) and benefits (e.g., improved viability in ethanol).

Ответ для heidiklumpe
H
heidiklumpe

Unexpectedly, we did not find evidence of large costs or benefits! Synthetic flocs grew exponentially and stably aggregated for 100s of generations. In ethanol and other toxins, they were as susceptible as our unicellular control.