A cool work from Ilya and Rotem on the 'damage-associated molecular pattern' that bacteria sense to detect phage attack (DNA degradation leading to increase in methylated nucleotides) and the immune response as abortive infection. www.science.org/doi/10.1126/...
Bacteria sense virus-induced genome degradation via methylated mononucleotidesPhages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...www.science.org