Congrats to NUCLEATE PI Veit Hornung on his newest publication in Gastroenterology! This collaborative study shows that STING ablation in T Cells is required for the efficacy of STING agonists in CAR-T Cell immunotherapy of pancreatic cancer. Read more: www.gastrojournal.org/article/S001...
STING Ablation in T Cells Is Required for the Efficacy of STING Agonists in CAR-T Cell Immunotherapy of Pancreatic CancerAblating the immune sensor STING in CAR-T cells enhances their effectiveness against
pancreatic cancer when combined with a STING-activating drug that boosts immune responses
in the tumor environment.www.gastrojournal.orgaga-gastroStudy finds that STING-deficient CAR-T cells + diABZI boost antitumor activity, increase CAR-T persistence, and improve tumor control in pancreatic cancer models, highlighting a potential new strategy for solid tumors. 🔗 https://ow.ly/JVzg50Zq3PM