In fact when we worked on applying splits networks to political data (see preprints.apsanet.org/engage/apsa/...) we also experimented with building splits networks from single-cell data and it was quite effective.
The Split SenateThe theory of split systems provides a mathematical formalism for understanding and visualizing collections of partitions of sets into two parts. In particular, split networks, which generalize phylog...preprints.apsanet.org