So, I decided to check and see what possible characters you can make and you can't make a Brujah or Lasombra of any kind without Potence or Oblivian, a Ventrue Neonate without Dominate or a Venture which purely uses fortitude,

𝕴𝖓𝖋𝖊𝖗𝖓𝖆𝖙𝖗𝖎𝖝 𝕾𝖔𝖕𝖍𝖎𝖆

Yes, another V6 post. I think it's really dumb to try to make Vampire a more streamlined plug-and-play game; the entire draw of Vampire is players are systemically encouraged to make thought out characters not just a bunch of stats thrown together hastily.