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Jan M. Ache

DopaMeander, in contrast, contributes to forward walking, but its activity is particularly linked to turning in the ipsiversive direction - so that the right DopaMeander contributes to rightward turns, and the left DopaMeander to leftward turns...

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Jan M. Ache

Finally, we leveraged the fact that we identified neurons controlling walking across hierarchical levels to ask how the brain ensures that appropriate motor output is generated in different behavioral states. To do so, we recorded MDN and DopaMeander in flies transitioning into and out of flight.

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Jan M. Ache

Both MDN and DopaMeander are gated out (switched off) during flight. Showing that behavioral state-dependent gating occurs simultaneously across levels of motor control and is bidirectional in nature, allowing the specific boosting of motor control modules in the appropriate behavioral context.

Ответ для Jan M. Ache
Jan M. Ache

This study was a team effort, with some surprises and directional changes on the way. I am grateful to the entire crew, especially Stefan & Sander, Fathima, Feffo, Mert, and Aleyna from my lab, Adrián and @postpop.bsky.social from the Clemens Lab, and Axel and Ansgar from the Büschges lab.

Ответ для Jan M. Ache
Jan M. Ache

We thank @dfg.de and the #NeuroNex program for generously funding our work, and our neighbours and colleagues at @uni-wuerzburg.de, especially the Department of Neurobiology and Genetics (Charlotte Förster, Chris Wegener, and @silkesachse.bsky.social). Stay tuned - more walking papers on the way...

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