I've updated the BINSEQ manuscript to stay up to date with changes since I originally put it out at the beginning of the year Some notable changes: 1. Support for ambiguous bases with 4bit encoding 2. Support for sequence headers 3. Improved API www.biorxiv.org/content/10.1...

BINSEQ: A Family of High-Performance Binary Formats for Nucleotide SequencesModern genomics produces billions of sequencing records per run, which are typically stored as gzip-compressed FASTQ files. While this format is widely used, it is not optimal for high-throughput proc...www.biorxiv.org