⟳ Репост от Patrick Moynihan
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial controlNature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due...rdcu.be